Single nucleotide polymorphism of CD40 region and the risk of systemic lupus erythematosus
Single nucleotide polymorphism of CD40 region and the risk of systemic lupus erythematosus
复制标题
DOI：
10.1177/0961203312470184
复制
发表时间：
2013-03
期刊：
影响因子：
2.6
通讯作者：
P. Piotrowski;P. Piotrowski;M. Lianeri;M. Wudarski;Marzena Olesińska;P. Jagodziński
中科院分区：
文献类型：
--
作者：
P. Piotrowski;P. Piotrowski;M. Lianeri;M. Wudarski;Marzena Olesińska;P. Jagodziński
There is one study on the association of the CD40 G > T (rs4810485) single nucleotide polymorphism (SNP) as a risk factor of systemic lupus erythematosus (SLE). Therefore, we studied the prevalence of the CD40 G > T SNP in patients with SLE (n = 261) and controls (n = 545) in a Polish population. We did not find significant differences between the CD40 G > T genotype and allele frequency in patients with SLE and healthy individuals. However, the frequency of the CD40 TT and GT genotypes was statistically different between patients with arthritis and neurologic manifestations and patients without these symptoms (OR = 0.2009 (95% CI = 0.07547–0.5348, p = 0.0004, pcorr = 0.0068) and OR = 0.2876 (95% CI = 0.1371–0.6031, p = 0.0005, pcorr = 0.0085) respectively). Our observations indicate that the CD40 T variant might be negatively associated with some clinical disease manifestations in patients with SLE.
