AcrAB and related multidrug efflux pumps of Escherichia coli.
AcrAB and related multidrug efflux pumps of Escherichia coli.
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DOI：
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发表时间：
2001-04
影响因子：
1.2
通讯作者：
Hiroshi Nikaido;H. Zgurskaya
中科院分区：
文献类型：
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作者：
Hiroshi Nikaido;H. Zgurskaya
大肠埃希菌AcrAB系统是由RND型转运体AcrB和周质辅助蛋白AcrA组成的多药物外排系统，通过TolC外膜通道将多种亲脂和两亲性抑制剂直接泵入培养基内。AcrA是一种高度伸长的蛋白质，被认为可以拉近外膜和内膜。它形成一个三聚体，与单体AcrB相互作用，体外重组表明AcrB是一个质子逆向转运体。之间交互的详细信息
The AcrAB system of Escherichia coli is a multidrug efflux system composed of an RND-type transporter AcrB and a periplasmic accessory protein AcrA, and pumps out a wide variety of lipophilic and amphiphilic inhibitors directly into the medium, presumably through the TolC outer membrane channel. AcrA, a highly elongated protein, is thought to bring the outer and inner membranes closer. It forms a trimer that interacts with a monomeric AcrB, which was shown by in vitro reconstitution to be a proton antiporter. Details of interaction between the