Nut Consumption and Blood Lipid Levels A Pooled Analysis of 25 Intervention Trials
Nut Consumption and Blood Lipid Levels A Pooled Analysis of 25 Intervention Trials
复制标题
DOI：
10.1001/archinternmed.2010.79
复制
发表时间：
2010-05-10
影响因子：
--
通讯作者：
Ros, Emilio
中科院分区：
文献类型：
--
作者：
Sabate, Joan;Oda, Keiji;Ros, Emilio
背景：流行病学研究一致认为坚果消费与冠心病风险降低有关。随后，许多饮食干预试验研究了坚果消费对血脂水平的影响。本研究的目的是估计坚果消费对血脂水平的影响，并研究是否不同的因素修改effects.Methods：我们汇总了25个坚果消费试验在7个国家的583名男性和女性血脂正常和高胆固醇血症谁不服用降脂药物的个人主要数据。在汇总分析中，我们使用混合线性模型来评估坚果消费量的影响和潜在的相互作用。结果：平均每日摄入67 g坚果，实现了以下估计的平均减少：总胆固醇浓度（10.9 mg/dL [5.1%变化]），低密度脂蛋白胆固醇浓度（LDL-C）（10.2 mg/dL [7.4%变化]），LDL-C与高密度脂蛋白胆固醇浓度（HDL-C）的比值（0.22 [8.3%变化]）和总胆固醇浓度与HDL-C的比值（0.24 [5.6%变化]）（P
Background: Epidemiological studies have consistently associated nut consumption with reduced risk for coronary heart disease. Subsequently, many dietary intervention trials investigated the effects of nut consumption on blood lipid levels. The objectives of this study were to estimate the effects of nut consumption on blood lipid levels and to examine whether different factors modify the effects.Methods: We pooled individual primary data from 25 nut consumption trials conducted in 7 countries among 583 men and women with normolipidemia and hyper-cholesterolemia who were not taking lipid-lowering medications. In a pooled analysis, we used mixed linear models to assess the effects of nut consumption and the potential interactions.Results: With a mean daily consumption of 67 g of nuts, the following estimated mean reductions were achieved: total cholesterol concentration (10.9 mg/dL [5.1% change]), low-density lipoprotein cholesterol concentration (LDL-C) (10.2 mg/dL [7.4% change]), ratio of LDL-C to high-density lipoprotein cholesterol concentration (HDL-C) (0.22 [8.3% change]), and ratio of total cholesterol concentration to HDL-C (0.24 [5.6% change]) (P