Gold-Catalyzed Direct Assembly of Aryl-Annulated Carbazoles from 2-Alkynyl Arylazides and Alkynes
Gold-Catalyzed Direct Assembly of Aryl-Annulated Carbazoles from 2-Alkynyl Arylazides and Alkynes
复制标题
金催化 2-炔基芳基叠氮化物和炔烃直接组装芳基环化咔唑
DOI：
10.1021/acs.orglett.6b01627
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发表时间：
2016-09-02
期刊：
影响因子：
5.2
通讯作者：
Gong, Liu-Zhu
中科院分区：
文献类型：
--
作者：
Li, Nan;Lian, Xiao-Lei;Gong, Liu-Zhu
本文报道了一种前所未有的金催化合成方法，即由2-炔基芳基叠氮化合物和炔直接组装成芳基环化咔唑。该反应建议进行通过一个顺序的环丙烯化和分子内金属卡宾/芳烃Friedel Crafts型反应，分别介导的两个金卡宾中间体。
An unprecedented gold-catalyzed synthetic method for the direct assembly of aryl-annulated carbazoles from 2-alkynyl arylazides and alkynes is described. The reaction is proposed to proceed via a sequential cyclopropenation and intramolecular metal carbene/arene Friedel Crafts-type reaction, respectively, mediated by two gold carbene intermediates.