Temporal Dissociation between Myeloperoxidase (MPO)-Modified LDL and MPO Elevations during Chronic Sleep Restriction and Recovery in Healthy Young Men
Temporal Dissociation between Myeloperoxidase (MPO)-Modified LDL and MPO Elevations during Chronic Sleep Restriction and Recovery in Healthy Young Men
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DOI：
10.1371/journal.pone.0028230
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发表时间：
2011-11-30
期刊：
影响因子：
3.7
通讯作者：
Kerkhofs, Myriam
中科院分区：
文献类型：
--
作者：
Boudjeltia, Karim Zouaoui;Faraut, Brice;Kerkhofs, Myriam
目的：许多研究评估了睡眠障碍可能影响炎症的方式，以及这种影响与心血管风险的可能联系。我们的目的是探讨慢性睡眠限制和恢复对几个血液心血管生物标志物的影响。方法和结果：9名健康的男性非吸烟者，年龄22-29岁，被送入睡眠实验室连续脑电图多导睡眠图下11天，夜。该研究包括三个8小时睡眠的基线夜晚（从晚上11点到早上7点），五个睡眠限制的夜晚，在此期间只允许在凌晨1点到早上6点之间睡眠，以及三个8小时睡眠的恢复夜晚（晚上11点到早上7点）。在睡眠限制期间，髓过氧化物酶修饰的低密度脂蛋白水平增加，表明氧化应激。在第一个恢复的夜晚，慢波睡眠的数量显着增加。经过这第一个恢复夜，胰岛素样生长因子-1水平的增加和髓过氧化物酶浓度peaked.Conclusions：我们观察到的第一次，睡眠限制和恢复过程与心血管疾病的血液生物标志物的差异变化。
Objectives: Many studies have evaluated the ways in which sleep disturbances may influence inflammation and the possible links of this effect to cardiovascular risk. Our objective was to investigate the effects of chronic sleep restriction and recovery on several blood cardiovascular biomarkers.Methods and Results: Nine healthy male non-smokers, aged 22-29 years, were admitted to the Sleep Laboratory for 11 days and nights under continuous electroencephalogram polysomnography. The study consisted of three baseline nights of 8 hours sleep (from 11 pm to 7 am), five sleep-restricted nights, during which sleep was allowed only between 1 am and 6 am, and three recovery nights of 8 hours sleep (11 pm to 7 am). Myeloperoxidase-modified low-density lipoprotein levels increased during the sleep-restricted period indicating an oxidative stress. A significant increase in the quantity of slow-wave sleep was measured during the first recovery night. After this first recovery night, insulin-like growth factor-1 levels increased and myeloperoxidase concentration peaked.Conclusions: We observed for the first time that sleep restriction and the recovery process are associated with differential changes in blood biomarkers of cardiovascular disease.