Sol-gel synthesis of amorphous calcium phosphate and sintering into microporous hydroxyapatite bioceramics
Sol-gel synthesis of amorphous calcium phosphate and sintering into microporous hydroxyapatite bioceramics
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DOI：
10.1111/j.1151-2916.1998.tb02499.x
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发表时间：
1998-06-01
影响因子：
3.9
通讯作者：
Tateishi, T
中科院分区：
文献类型：
--
作者：
Layrolle, P;Ito, A;Tateishi, T
介绍了一种制备羟基磷灰石（Ca-10（PO_4）（6）（OH）（2））生物陶瓷的新方法。以二乙醇钙和磷酸为原料，采用溶胶-凝胶法合成了钙磷比为1.67的无定形纳米级磷酸钙粉体。在98 MPa下将该粉末压制成绿色样品，然后加热至500 ℃-1300 ℃的温度范围。在600摄氏度下，该粉末结晶为碳酸化的羟基磷灰石和微量的β-磷酸三钙，然后在900摄氏度下转化为羟基磷灰石。热结晶与晶粒生长、收缩和活性表面扩散有关。晶粒生长的活化能为37 +/-2kJ/mol。在1100 ℃下烧结后，碳酸化羟基磷灰石的分解产生了平均孔径为0.2 μ m和开口孔隙率为15.5%的微孔陶瓷。这种微孔生物陶瓷可用作骨填充物。
A new route for preparing hydroxyapatite (Ca-10(PO4)(6)(OH)(2)) bioceramic has been described. An amorphous, nanosized, and carbonate-containing calcium phosphate powder that had a Ca:P ratio of 1.67 was synthesized from calcium diethoxide and phosphoric acid in ethanol via a sol-gel method. The ponder was pressed at 98 MPa into green specimens and then heated to a temperature range of 500 degrees-1300 degrees C. At 600 degrees C, the ponder crystallized to a carbonated hydroxyapatite and a trace of beta-tricalcium phosphate before converting to hydroxyapatite at 900 degrees C. The thermal crystallization was associated with grain growth, shrinkage, and active surface diffusion. The activation energy of grain growth was 37 +/- 2 kJ/mol, After sintering at 1100 degrees C, the decomposition of carbonated hydroxyapatite generated a microporous ceramic with an average pore size of 0.2 mu m and an open porosity of 15.5%. This microporous bioceramic can be used as a bone filler.