Adventures within the speckled band: heterogeneity, angiogenesis, and balanced inflammation in the tuberculous granuloma.
Adventures within the speckled band: heterogeneity, angiogenesis, and balanced inflammation in the tuberculous granuloma.
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DOI：
10.1111/imr.12273
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发表时间：
2015-03
影响因子：
8.7
通讯作者：
Tobin DM
中科院分区：
文献类型：
--
作者：
Matty MA;Roca FJ;Cronan MR;Tobin DM
最近在各种动物模型，包括小鼠，斑马鱼和猕猴，以及在人类中的工作，导致了分枝杆菌感染的几个原则的重新评估。在这篇综述中，我们强调了结核性肉芽肿的组成和动力学的新发现，分枝杆菌感染的中央宿主结构，以及炎症介质，一方面驱动成功的抗微生物反应，另一方面病理性炎症。我们强调肉芽肿的异质性，出现在感染的背景下，在结核性肉芽肿血管生成的功能性后果，和数据，平衡炎症在人类中，肿瘤坏死因子的核心作用，似乎发挥了关键作用，在最佳防御分枝杆菌感染。这些发现提示了新的和特异性的宿主导向疗法，有待于进一步的临床探索。
Recent work in a variety of animal models, including mice, zebrafish, and macaques, as well as in humans, has led to a reassessment of several tenets of mycobacterial infection. In this review, we highlight new findings about the composition and dynamics of the tuberculous granuloma, the central host structure in mycobacterial infection, as well as inflammatory mediators that drive a successful anti-microbial response on one hand and pathological inflammation on the other. We highlight granuloma heterogeneity that emerges in the context of infection, the functional consequences of angiogenesis in tuberculous granulomas, and data that balanced inflammation in humans, with a central role for tumor necrosis factor, appears to play a key role in optimal defense against mycobacterial infection. These findings have suggested new and specific host-directed therapies that await further clinical exploration.