Quality of life in rectal cancer patients after radical surgery: a survey of Chinese patients.
Quality of life in rectal cancer patients after radical surgery: a survey of Chinese patients.
复制标题
直肠癌根治术后患者的生活质量：中国患者的调查
DOI：
10.1186/1477-7819-12-161
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发表时间：
2014-05-22
影响因子：
3.2
通讯作者：
Xu K
中科院分区：
文献类型：
--
作者：
Li X;Song X;Chen Z;Li M;Lu L;Xu Y;Zhan W;He Y;Xu K
我们的目的是调查社会人口学和临床特征对中国大陆人群直肠癌根治术后无病生存者健康相关生活质量（HRQoL）的影响。我们从2002年8月至2011年2月使用欧洲癌症研究与治疗组织（EORTC）QLQ-C30和QLQ-CR 38问卷对438例接受根治性手术的直肠癌患者进行了横断面调查。要求随访至少6个月、无相关主要合并症且疾病未复发的患者完成两份问卷。通过单因素和多因素回归分析比较社会人口学和临床特征对HRQoL的影响。共有285名患者对调查做出了回应（回应率为65.1%）。年轻患者的心理相关HRQoL变量（如情绪功能（P = 0.021）和未来前景（P = 0.044））比老年患者差;生理相关HRQoL反映为身体功能（P = 0.039），老年患者比年轻患者差。在生理功能和HRQoL相关症状方面，如疼痛（P = 0.002）和失眠（P = 0.018），女性的数值低于男性。低教育和失业与更差的HRQoL相关。有造口的患者HRQoL较无造口的患者差，尤其是在社会心理方面，如角色功能（P = 0.025）、社会功能（P <0.001）和身体形象（P = 0.004）。年轻患者和造口患者的财务HRQoL更差。在中国大陆直肠癌患者中，与许多社会人口学和临床因素相比，直肠癌根治术后HRQoL方面和受损程度不同。
We aimed to investigate the impact of sociodemographic and clinical characteristics on health-related quality of life (HRQoL) in disease-free survivors after radical surgery for rectal cancer in a Chinese mainland population. We performed a cross-sectional survey from August 2002 to February 2011 by use of the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and QLQ-CR38 questionnaires of 438 patients who underwent curative surgery for rectal cancer. Patients who were followed up for a minimum of 6 months, had no relevant major comorbidities and whose disease had not recurred were asked to complete both questionnaires. The impact of sociodemographic and clinical characteristics on HRQoL were compared by univariate and multivariate regression analyses. In total, 285 patients responded to the survey (response rate, 65.1%). Psychological-related HRQoL variables such as emotional function (P = 0.021) and future perspectives (P = 0.044) were poorer for younger patients than for older patients; and physiological-related HRQoL was reflected by physical function (P = 0.039), which was poorer for older patients than for younger patients. In terms of physiologic function and symptoms concerning HRQoL, such as pain (P = 0.002) and insomnia (P = 0.018), females had lower values than males. Low education and unemployment were associated with a worse HRQoL. HRQoL was worse for patients with stomas compared to those without, especially in psychosocial areas such as role function (P = 0.025), social function (P <0.001) and body image (P = 0.004). Financial HRQoL was worse for younger patients and patients with stoma. HRQoL aspects and degrees to which they were impaired after curative surgery for rectal cancer were different when compared by many sociodemographic and clinical factors in Chinese mainland patients.
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DOI：
10.1016/j.ijrobp.2009.03.010
发表时间：
2010-03-15
影响因子：
7
作者：
Bruheim, Kjersti;Guren, Marianne G.;Tveit, Kjell Magne
通讯作者：
Tveit, Kjell Magne
影响因子：
3.6
作者：
Parker, PA;Baile, WF;Cohen, L
通讯作者：
Cohen, L
DOI：
10.1093/jnci/85.5.365
发表时间：
1993-03-03
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
AARONSON, NK;AHMEDZAI, S;TAKEDA, F
通讯作者：
TAKEDA, F
影响因子：
45.3
作者：
Krouse, Robert S.;Herrinton, Lisa J.;Hornbrook, Mark C.
通讯作者：
Hornbrook, Mark C.
影响因子：
3.4
作者：
Celasin, H.;Karakoyun, R.;Kuzu, M. A.
通讯作者：
Kuzu, M. A.