Immediate causes of death in acquired immunodeficiency syndrome.
Immediate causes of death in acquired immunodeficiency syndrome.
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获得性免疫缺陷综合征死亡的直接原因。
DOI：
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发表时间：
1985
影响因子：
4.6
通讯作者：
K. Adams
中科院分区：
文献类型：
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作者：
L. Moskowitz;G. Hensley;Chan Jc;K. Adams
我们评估了 1980 年 4 月至 1983 年 10 月期间接受尸检并被诊断死于获得性免疫缺陷综合症的 54 名成年人的直接死亡原因。研究小组包括 25 名海地人、19 名同性恋男性、5 名静脉注射吸毒者、2 名血友病患者（A 型）和 3 名无已知风险的患者。 14人死于中枢神经系统疾病：弓形虫脑炎11人，进行性多灶性白质脑病1人，病毒性脑炎1人，脑出血1人。三十人死于呼吸衰竭；卡氏肺孢子虫肺炎16例，巨细胞病毒肺炎10例，多重感染1例，间质性肺炎1例，细菌性肺炎2例。两人死于压倒性的全身感染：一名是胞内分枝杆菌，一名是李斯特菌病。六人死于播散性卡波西肉瘤，其余两人分别死于弓形虫心肌炎（一人）和一人死于经皮肝活检引起的休克。海地人和同性恋者之间的直接死亡原因存在以下差异：63% 的同性恋者死于卡氏肺结核或卡波西肉瘤，而海地人为 20%。相比之下，72% 的海地人死于其他机会性感染，而同性恋者的这一比例为 21%。自1982年以来，死前诊断的病例比例一直没有增加，总体而言，只有32例（58%）是死前诊断的；其余的仅在尸检时确诊。这项研究提供的证据表明，42% 的人死于目前无法治疗的疾病。
We evaluated the immediate causes of death in 54 adults who underwent an autopsy and were diagnosed as having died of the acquired immunodeficiency syndrome between April 1980 and October 1983. The study group included 25 Haitians, 19 homosexual men, five intravenous drug abusers, two hemophiliacs (type A), and three with no known risk. Fourteen died of central nervous system diseases: 11 of Toxoplasma encephalitis, one of progressive multifocal leukoencephalopathy, one of viral encephalitis, and one of intracerebral hemorrhage. Thirty died of respiratory failure; 16 of Pneumocystis carinii pneumonia, ten of cytomegalovirus pneumonia, one of multiple infections, one of interstitial pneumonia, and two of bacterial pneumonia. Two died of overwhelming generalized infections: one of Mycobacterium avium-intracellulare and one of listeriosis. Six died of disseminated Kaposi's sarcoma, while the remaining two persons died of Toxoplasma myocarditis (one) and one of shock resulting from a percutaneous liver biopsy, respectively. There were differences in the immediate causes of death between Haitians and homosexuals as follows: 63% of homosexual men died of either P carinii pneumonia or Kaposi's sarcoma vs 20% of Haitians. In contrast, 72% of Haitians died of other opportunistic infections as compared with 21% of homosexuals. There has not been an increase in the proportion of cases diagnosed premortem since 1982 and overall, only 32 (58%) were diagnosed premortem; the rest were diagnosed only at autopsy. This study provided evidence that 42% died of currently untreatable diseases.