Impact of Environmental Air Pollutants on Disease Control in Asmathic Patients
Impact of Environmental Air Pollutants on Disease Control in Asmathic Patients
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DOI：
10.1007/s00408-015-9695-9
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发表时间：
2015-04-01
期刊：
影响因子：
5
通讯作者：
Casan, Pere
中科院分区：
文献类型：
--
作者：
Fernandez, Ramon;Ariza, Miguel;Casan, Pere
哮喘患者受到空气污染物的不利影响，现在可以测量其浓度。然而，这一信息在临床实践中的效用尚未确定在一组哮喘病情稳定。我们的目的是确定空气污染物水平对哮喘控制和气道炎症程度的影响。我们对病情稳定的成人哮喘患者进行了横断面研究。我们从区域环境管理局获得了固定地理点的环境一氧化氮（NO2）、臭氧（O-3）、直径达10微米的悬浮颗粒物（PM10）和二氧化硫（SO2）的浓度。使用哮喘控制试验（ACT）评分评估疾病控制，使用呼出气一氧化氮（FeNO）值评估气道炎症。以ACT评分为因变量进行相关和线性回归研究，研究包括99名哮喘患者，年龄39岁（SD 8），55%为女性。平均ACT值为17.2（SD 6.5），FeNO为33.7（SD 16）。在研究的污染物中，只有NO2与ACT评分相关（CC = 0.45，p < 0.001）。我们没有发现污染物和气道炎症之间的关系。多变量分析表明，ACT评分预测环境空气中NO2浓度，在较小程度上，平均FeNO。在我们的环境中的环境NO2浓度的信息可以帮助临床医生解释哮喘患者的演变。
Asthmatics are adversely affected by the presence of air pollutants, the concentrations of which can nowadays be measured. However, the utility of this information in clinical practice has not been defined in a group of asthmatics in stable condition. Our objective was to determine what impact the level of air pollutants had on the control of their asthma and the degree of airway inflammation.We performed a cross-sectional study of adult asthmatics in stable condition. From the regional environmental authority, we obtained the concentrations of ambient nitric oxide (NO2), ozone (O-3), suspended particulate matter up to 10 micrometers in diameter (PM10) and sulphur dioxide (SO2) at fixed geographical points. Disease control was assessed using asthma control test (ACT) scores, and airway inflammation using fraction of exhaled nitric oxide (FeNO) values. Correlation and linear regression studies were performed using ACT scores as the dependent variable.The study included 99 asthmatics, aged 39 years (SD 8), 55 % women. Mean ACT value was 17.2 (SD 6.5), and FeNO 33.7 (SD 16). Of the pollutants studied, only NO2 was correlated with ACT scores (CC = 0.45, p < 0.001). We found no relationship between pollutants and airway inflammation. Multivariate analysis showed that ACT score was predicted by ambient air NO2 concentration and, to a lesser extent, mean FeNO.Information on the concentration of ambient NO2 in our environment can help the clinician to interpret the evolution of asthmatic patients.