Structure and dynamics of macrophage podosomes

Structure and dynamics of macrophage podosomes
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DOI:
10.1016/j.ejcb.2005.08.006
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发表时间:
2006-04-01
影响因子:
6.6
通讯作者:
Matsudaira, P
Matsudaira, P
中科院分区:
生物学3区
文献类型:
--
作者:
Evans, JG;Matsudaira, P

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足小体是短暂的、富含动态肌动蛋白的粘连,通常在巨噬细胞、破骨细胞和 Src 转化的成纤维细胞中形成。尽管与更常研究的粘着斑相关,共享多种结构和调节蛋白,但足体具有独特的功能、结构和动态特征。在这里,我们讨论目前对不同细胞类型中足体功能的理解,以及这与其结构和动力学的关系。 (c) 2005 年爱思唯尔有限公司。版权所有。
Podosomes are short-lived, dynamic actin-rich adhesions classically formed in macrophages, osteoclasts and Srctransformed fibroblasts. Though related to the more commonly studied focal adhesions, sharing several structural and regulatory proteins, podosomes have distinct functional, structural, and dynamic characteristics. Here, we discuss current understanding of the function of podosomes in disparate cell types and how this relates to their structure and dynamics. (c) 2005 Elsevier GmbH. All rights reserved.