Rapid Flow-Based System for Separation of Radioactive Metals by Selective Complex Formation
Rapid Flow-Based System for Separation of Radioactive Metals by Selective Complex Formation
复制标题
通过选择性络合形成分离放射性金属的基于快速流的系统
DOI：
10.1021/acs.analchem.1c03866
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发表时间：
2021
影响因子：
7.4
通讯作者：
Ohira Shin-Ichi
中科院分区：
文献类型：
--
作者：
Sugo Yumi;Miyachi Ryoma;Obata Syohei;Maruyama Yo-hei;Manabe Hinako;Mori Masanobu;Ishioka Noriko S.;Toda Kei;Ohira Shin-Ichi
短寿命放射性金属是临床诊断的重要示踪剂。临床使用的放射性金属是在回旋加速器中从合适的靶金属生产的。产生的微量放射性金属包含在相对大量的目标金属中。需要一种快速有效的方法来分离放射性金属。在本研究中，选择性络合物的形成，然后进行阳离子交换吸附在一个连续的流动为基础的系统。通过模拟实验，选择乙二胺-N，N，N′，N′-四乙酸（EDTA）为配体，对Ga与Zn的分离进行了研究。选择性地，Ga-EDTA络合物通过阳离子阱，而Zn 2+被捕获。这种分离原理与捕获目标离子的典型固相萃取相反。所提出的分离是在基于流动的系统中进行的，该系统具有平行的开放通道离子阱。通过改变通道尺寸、通道填充网格和流速来优化性能。最后，从50 fg Ga/L和100 mg Zn/L的混合物中选择性地和有效地（>99%）分离目标放射性金属Ga。Ga溶液中残留的Zn浓度为2.3 μg/L。通过简单的UV照射方法将络合的Ga转化为游离的Ga 3+。所提出的方法使用可以在现场操作的简单流动系统，有效且快速地分离大量目标金属中所含的痕量放射性金属。
Short-lived radioactive metals are important tracers in clinical diagnosis. Radioactive metals for clinical use are produced from suitable target metals in cyclotrons. The trace amount of radioactive metal produced is contained in a relatively large amount of target metal. A rapid and effective method is required to isolate the radioactive metal. In the present study, selective complex formation followed by cation-exchange adsorption was performed in a continuous flow-based system. Ethylenediamine-N,N,N′,N′-tetraacetic acid (EDTA) was selected as the ligand after simulation of the separation of radioactive Ga from the target (Zn). Selectively, the Ga–EDTA complex passed through the cation trap, while Zn2+was trapped. This separation principle is opposite to that of typical solid-phase extraction, which captures the target ion. The proposed separation was performed in a flow-based system with a parallel, open-channel ion trap. The performance was optimized by altering the channel dimensions, channel-filling mesh, and flow rate. Finally, the target radioactive metal, Ga, was selectively and effectively (>99%) separated from a mixture of 50 fg Ga/L and 100 mg Zn/L. The concentration of Zn remaining in the Ga solution was 2.3 μg/L. The complexed Ga was converted to free Ga3+by a simple UV irradiation method. The proposed method effectively and rapidly separates trace amounts of radioactive metals contained in larger amounts of target metals using a simple flow system that can be operated on site.