Maternal vitamin D intake during pregnancy and early childhood wheezing
Maternal vitamin D intake during pregnancy and early childhood wheezing
复制标题
DOI：
10.1093/ajcn/85.3.853
复制
发表时间：
2007-03-01
影响因子：
7.1
通讯作者：
Weiss, Scott T.
中科院分区：
文献类型：
--
作者：
Devereux, Graham;Litonjua, Augusto A.;Weiss, Scott T.
背景资料：母亲在怀孕期间摄入维生素D是一个潜在的可改变的但未充分研究的儿童哮喘发病的危险因素。目的：我们调查母亲在怀孕期间摄入维生素D是否与幼儿喘息症状风险降低有关。设计：受试者来自子宫内招募的出生队列，主要目的是确定妊娠期间母亲饮食与哮喘和过敏之间的关系小儿随机抽取2000名健康孕妇，在苏格兰阿伯丁妇产医院产前门诊就诊，妊娠期约12周。母亲维生素D摄入量确定的食物频率问卷完成在妊娠32周。主要结果的措施是喘息症状，肺功能测定，支气管扩张剂反应，过敏性反应，并呼出一氧化氮在5 y.Results：呼吸系统的细节，通过5 y和母亲的食物频率问卷调查数据，可用于1212名儿童。在调整了潜在混杂因素（包括儿童维生素D摄入量）的模型中，比较母亲总维生素D摄入量的最高和最低五分位数，可以降低发生喘息的风险[比值比（OR）：0.48; 95%CI：0.25，0.91]，（OR：0.35; 95%CI：0.15，0.83）和持续喘息（OR：0.33; 95%CI：0.11，0.98）。此外，孕妇维生素D总摄入量较低也与支气管扩张剂反应降低相关（P = 0.04）。孕妇维生素D摄入量和肺功能或呼出的一氧化氮concentration.Conclusion：增加孕妇维生素D摄入量在怀孕期间可能会降低儿童早期喘息症状的风险之间没有关联。
Background: Maternal intake of vitamin D in pregnancy is a potentially modifiable but understudied risk factor for the development of asthma in children.Objective: We investigated whether maternal vitamin D intake in pregnancy is associated with decreased risks of wheezing symptoms in young children.Design: Subjects were from a birth cohort recruited in utero with the primary objective of identifying associations between maternal diet during pregnancy and asthma and allergies in children. A random sample of 2000 healthy pregnant women was recruited while attending antenatal clinics at the Aberdeen Maternity Hospital, Scotland, at approximate to 12 wk gestation. Maternal vitamin D intake was ascertained from a food-frequency questionnaire completed at 32 wk of gestation. The main outcome measures were wheezing symptoms, spirometry, bronchodilator response, atopic sensitization, and exhaled nitric oxide at 5 y.Results: Respiratory details through 5 y and maternal food-frequency-questionnaire data were available for 1212 children. In models adjusted for potential confounders, including the children's vitamin D intake, a comparison of the highest and lowest quintiles of maternal total vitamin D intake conferred lower risks for ever wheeze [odds ratio (OR): 0.48; 95% CI: 0.25, 0.91], wheeze in the previous year(OR: 0.35; 95% CI: 0.15, 0.83), and persistent wheeze (OR: 0.33; 95%CI: 0.11, 0.98) in 5-y-old children. In addition, lower maternal total vitamin D intakes in pregnancy were also associated with decreased bronchodilator response (P = 0.04). No associations were observed between maternal vitamin D intakes and spirometry or exhaled nitric oxide concentrations.Conclusion: Increasing maternal vitamin D intakes during pregnancy may decrease the risk of wheeze symptoms in early childhood.