Zonal distribution of sulfotransferase for phenol in olfactory sustentacular cells
Zonal distribution of sulfotransferase for phenol in olfactory sustentacular cells
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DOI：
10.1002/j.1460-2075.1996.tb00558.x
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发表时间：
1996-05-01
期刊：
影响因子：
11.4
通讯作者：
Mikoshiba, K
中科院分区：
文献类型：
--
作者：
Miyawaki, A;Homma, H;Mikoshiba, K
我们有免疫定位的苯酚磺基转移酶（PST）G，PST的亚型在支持细胞，驻留在背内侧部分的小鼠鼻腔。一些嗅觉神经元特异性基因的基因表达也有相同的地形图模式，（含酚）气味剂被用作底物，小鼠鼻组织胞质溶胶显示出显著水平的PST活性，小鼠肝胞质溶胶也是如此。这项研究首次证明嗅觉支持细胞中的基因表达也是带状组织的，并表明磺基共轭参与嗅觉受体周围过程，如气味清除和异生物质解毒。
We have immunolocalized phenol sulfotransferase (PST)G, an isoform of PST in sustentacular cells which reside in the dorso-medial portion of the nasal cavity of the mouse. The same topographical pattern of gene expression has been reported for some olfactory neuron-specific genes, When several established (phenol-containing) odorants were used as substrates, mouse nasal tissue cytosol showed a significant level of PST activity, as does mouse liver cytosol, This study is the first to demonstrate that gene expression in the olfactory sustentacular cells is also organized zonally, and indicates the involvement of sulfo-conjugation in olfactory perireceptor processes, such as odorant clearance and xenobiotic detoxification.