Notch signaling and neurogenesis in normal and stroke brain.
Notch signaling and neurogenesis in normal and stroke brain.
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发表时间：
2009
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通讯作者：
Mei-Juan Xiao;Zhao Han;B. Shao;K. Jin
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作者：
Mei-Juan Xiao;Zhao Han;B. Shao;K. Jin
成体神经干细胞(NSCs)由于其在中枢神经系统中的独特位置、增殖和分化为所有主要神经谱系的潜力以及在中风后功能整合到现有神经元回路的能力，在脑修复方面具有巨大的前景。然而，由于缺乏对控制中风后成年神经干细胞产生功能神经元的信号的了解，尤其是在老化的大脑中，开发这些细胞用于治疗目的的能力受到了阻碍。因此，为了进一步确定卒中后神经发生的调控机制，发展未来基于神经干细胞的修复策略至关重要。Noch信号定义了一条控制细胞命运获得的基本途径。研究表明，Notch信号通路在发育中的脑内神经干细胞的维持、增殖和分化过程中起着关键作用。最近的证据表明，Notch1信号在成人神经发生的调控中是保守的。在这里，我们总结了目前关于Notch信号在正常和中风脑中神经发生调控中的作用的知识。
Adult neuronal stem cells (NSCs) hold great promise for brain repair because of their unique location within the central nervous system, their potential to proliferate and to differentiate into all major neural lineages, and their ability to functionally incorporate into existing neuronal circuitry after stroke. Nevertheless, the ability to exploit these cells for therapeutic purposes is hampered by the lack of knowledge about the signals that control the generation of a functional neuron from adult NSCs after stroke, particularly in the aged brain. Therefore, to further define the regulatory mechanisms that underlie neurogenesis after stroke, it is critically important to develop future NSC-based repair strategies. Notch signaling defines a fundamental pathway controlling cell fate acquisition. Studies have shown that Notch signaling pathways play critical roles during the maintenance, proliferation, and differentiation of NSCs in the developing brain. Recent evidence shows that Notch1 signaling is conserved in the regulation of adult neurogenesis. Here we summarize current knowledge about the role of Notch signaling in the regulation of neurogenesis in the normal and stroke brain.