Fabrication of novel magnetic nanoparticles-coated P(styrene-itaconic acid-divinylbenzene) microspheres

Fabrication of novel magnetic nanoparticles-coated P(styrene-itaconic acid-divinylbenzene) microspheres
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新型磁性纳米粒子包覆P(苯乙烯-衣康酸-二乙烯基苯)微球的制备

DOI:
10.1016/j.carbpol.2011.11.063
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发表时间:
2012-03
影响因子:
11.2
通讯作者:
Li, WeiFeng
Li, WeiFeng
中科院分区:
化学1区
文献类型:
--
作者:
Xing, JianFeng;Li, XingYi;Fu, Qiang;Li, WeiFeng

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以苯乙烯(St)、衣康酸(IA)和二乙烯基苯(DVB)为原料,在粒径为5-10μm的乳化剂存在下,采用油包水乳液法(W/O)制备了P(St-IA-DVB)微球。在连续搅拌下,在水中制备了磁性纳米粒子Fe 3 O 4,并将其紧密包覆在P(St-IA-DVB)微球表面。研究了空白微球和磁性纳米粒子包覆微球的形貌。以阿霉素为模型药物,研究了磁性纳米粒子包覆的P(St-IA-DVB)(MNPSID)微球的体外释药行为,结果表明,磁性纳米粒子包覆的P(St-IA-DVB)(MNPSID)微球在磁靶向治疗和热疗方面具有潜在的应用价值。
In this paper, P(styrene-itaconic acid-divinylbenzene) microspheres (P(St-IA-DVB) microspheres) based on styrene (St), itaconic acid (IA) and divinylbenzene (DVB) were prepared via water-in-oil emulsions method (W/O) in the presence of emulsifiers with the size of 5–10μm. The magnetic nanoparticles (i.e. Fe3O4) coated tightly on the surface of P(St-IA-DVB) microspheres were prepared in water with a continuous stirring. The morphology of blank microspheres and magnetic nanoparticles-coated microspheres was investigated in this work. In vitro drug release behavior was studied using doxorubicin as a model drug, and these magnetic nanoparticles-coated P(St-IA-DVB) (MNPSID) microspheres might have great potential application in magnetically targeted and thermal therapy.
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