Increased serum levels of inflammatory markers in chronic institutionalized patients with schizophrenia
Increased serum levels of inflammatory markers in chronic institutionalized patients with schizophrenia
复制标题
DOI：
10.1159/000148197
复制
发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Teixeira, Antonio Lucio
中科院分区：
文献类型：
--
作者：
Coelho, Fernanda Matos;Reis, Helton Jose;Teixeira, Antonio Lucio
细胞因子系统的激活可能参与了精神分裂症患者中枢神经系统的神经病理改变。然而，细胞因子水平与症状严重程度之间的关系尚未完全确定。目的：评价精神分裂症患者和健康对照者血清中肿瘤坏死因子(TNF)- α及其可溶性受体（sTNFR）的水平。方法：招募40例男性精神分裂症住院患者（平均年龄+/- SD， 52.3 +/- 9.9岁）和20例无症状对照。采用简易精神病学评定量表、阳性和阴性综合征量表和异常不自主运动量表评估症状的严重程度。elisa法检测血清细胞因子水平。结果：精神分裂症患者血清sTNFR1和sTNFR2水平较对照组升高（p均< 0.05），但tnf - α水平无显著差异。疾病/住院时间或症状严重程度与这些分子的血清水平之间没有相关性。结论：精神分裂症患者炎症指标升高，但与症状严重程度无关。版权所有2008 S. Karger AG，巴塞尔
Activation of the cytokine systems may be involved in the neuropathological changes occurring in the central nervous systems of schizophrenic patients. However, associations between the levels of cytokines and the severity of symptoms have not been completely established. Objective: It was the aim of this study to evaluate serum levels of tumor necrosis factor (TNF)-alpha and their soluble receptors (sTNFR) in schizophrenic patients and healthy controls. Methods: Forty male institutionalized schizophrenic patients (mean age +/- SD, 52.3 +/- 9.9 years) and 20 asymptomatic matched controls were recruited. The severity of symptoms was assessed using the Brief Psychiatric Rating Scale, the Positive and Negative Syndrome Scale and the Abnormal Involuntary Movement Scale. Serum levels of cytokines were measured by ELISAs. Results: Serum levels of sTNFR1 and sTNFR2 were increased in schizophrenic patients when compared with controls ( all p < 0.05), but there was no difference in TNF-alpha levels. There was no correlation between the length of disease/hospitalization or the severity of symptoms and the serum levels of these molecules. Conclusion: Inflammatory markers are increased in schizophrenia but they do not correlate with symptom severity. Copyright (C) 2008 S. Karger AG, Basel.