MR quantification of hepatic iron concentration
MR quantification of hepatic iron concentration
复制标题
DOI：
10.1148/radiol.2302020820
复制
发表时间：
2004-02-01
期刊：
影响因子：
19.7
通讯作者：
Recondo, JA
中科院分区：
文献类型：
--
作者：
Alústiza, JM;Artetxe, J;Recondo, JA
PURPOSE: To evaluate the accuracy of magnetic resonance (MR) imaging in the quantification of hepatic iron concentration.MATERIALS AND METHODS: Between April 1999 and June 2001, 112 patients were recruited prospectively. All had undergone liver biopsy and hepatic iron concentration quantification with spectrophotometry, followed by MR imaging. MR imaging involved use of four gradient-echo sequences and one spin-echo sequence. Signal intensity (SI) was measured on images obtained with each sequence by means of regions of interest placed in the liver and paraspinal muscle to. obtain the liver-to-muscle SI ratio. The relationship between hepatic iron concentration and SI ratio for each sequence was analyzed with multiple linear regression. Receiver operating characteristic analysis was performed to find the diagnostic thresholds.RESULTS: Sixty-eight patients had normal hepatic iron levels (80 mumol/g).With all sequences, an inverse linear relationship between iron concentration and SI ratio was apparent. The authors generated a mathematic model to estimate the iron concentrations from MR imaging data (r = 0.937). For estimated concentrations of more than 85mumol/g, the positive predictive value for hemochromatosis was 100%; for those less than 40 mumol/g, the negative predictive value for hemochromatosis was 100%. For estimated concentrations of more than 58 mumol/g, the positive predictive value for iron overload was 100%; for those less than 20 mumol/g, the negative predictive value for iron overload was 100%.CONCLUSION: MR imaging is a useful and noninvasive diagnostic tool for quantification of hepatic iron concentration. (C) RSNA, 2003.
