Calcium-dependent regulation of glucose homeostasis in the liver
Calcium-dependent regulation of glucose homeostasis in the liver
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DOI：
10.1016/j.ceca.2014.02.007
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发表时间：
2014-06-01
期刊：
影响因子：
4
通讯作者：
Thomas, Andrew P.
中科院分区：
文献类型：
--
作者：
Bartlett, Paula J.;Gaspers, Lawrence D.;Thomas, Andrew P.
肝脏的主要作用是整合多种信号以维持正常的血糖水平。葡萄糖储存和动员之间的平衡主要由胰岛素和胰高血糖素的抵消作用调节。然而，许多信号在肝脏中汇聚，以确保能量需求与生物体的生理状态相匹配。许多循环激素通过钙依赖性信号机制调节糖原分解、糖原生成和线粒体代谢，这些机制表现为胞质Ca 2+振荡。刺激强度被编码在Ca 2+振荡频率中，并且还被完整肝脏中细胞间Ca 2+波传播的范围编码。在本文中，我们描述了Ca 2+振荡和波如何调节完整肝脏中的葡萄糖输出和氧化代谢;如何通过器官水平的Ca 2+信号传导解码多种刺激，以及Ca 2+信号失调对代谢综合征等疾病的影响和非酒精性脂肪肝疾病。(C)2014由Elsevier Ltd.出版
A major role of the liver is to integrate multiple signals to maintain normal blood glucose levels. The balance between glucose storage and mobilization is primarily regulated by the counteracting effects of insulin and glucagon. However, numerous signals converge in the liver to ensure energy demand matches the physiological status of the organism. Many circulating hormones regulate glycogenolysis, gluconeogenesis and mitochondrial metabolism by calcium-dependent signaling mechanisms that manifest as cytosolic Ca2+ oscillations. Stimulus-strength is encoded in the Ca2+ oscillation frequency, and also by the range of intercellular Ca2+ wave propagation in the intact liver. In this article, we describe how Ca2+ oscillations and waves can regulate glucose output and oxidative metabolism in the intact liver; how multiple stimuli are decoded though Ca2+ signaling at the organ level, and the implications of Ca2+ signal dysregulation in diseases such as metabolic syndrome and non-alcoholic fatty liver disease. (C) 2014 Published by Elsevier Ltd.