DNA structure checkpoint pathways in Schizosaccharomyces pombe
DNA structure checkpoint pathways in Schizosaccharomyces pombe
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DOI：
10.1016/s0300-9084(99)80050-9
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发表时间：
1999-01-01
期刊：
影响因子：
3.9
通讯作者：
Carr, AM
中科院分区：
文献类型：
--
作者：
Caspari, T;Carr, AM
对DNA损伤的反应包括延迟细胞周期的进展，以帮助DNA修复错误复制的染色体(复制检查点)或DNA损伤(DNA损伤检查点)延迟有丝分裂的开始。这些检查点通路检测DNA扰动并产生信号。信号被放大并传输到细胞周期机器。由于检查点通路对基因组的稳定性至关重要，因此在所有真核生物(从酵母到哺乳动物)中发现的相关蛋白有望具有与酵母前体相似的功能。本文综述了检查点蛋白在裂殖酵母模型系统中的功能。简要提到酿酒酵母和哺乳动物细胞中的检查点控制，以强调共同或不同的特征。(C)巴黎Moleculaire/Elsevier法国兴业银行。
The response to DNA damage includes a delay to progression through the cell cycle to aid DNA repair Incorrectly replicated chromosomes (replication checkpoint) or DNA damage (DNA damage checkpoint) delay the onset of mitosis. These checkpoint pathways detect DNA perturbations and generate a signal. The signal is amplified and transmitted to the cell cycle machinery. Since the checkpoint pathways are essential for genome stability, the related proteins which are found in all eukaryotes (from yeast to mammals) are expected to have similar functions to the yeast progenitors. This review article focuses on the function of checkpoint proteins in the model system Schizosaccharomyces pombe. Checkpoint controls in Saccharomyces cerevisiae and mammalian cells are mentioned briefly to underscore common or diverse features. (C) Societe francaise de biochimie et biologie moleculaire / Elsevier, Paris.