Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G: A possible role in the resistance to HIV of HIV-exposed seronegative individuals
Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G: A possible role in the resistance to HIV of HIV-exposed seronegative individuals
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DOI：
10.1086/511988
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发表时间：
2007-04-01
影响因子：
6.4
通讯作者：
Clerici, Mario
中科院分区：
文献类型：
--
作者：
Biasin, Mara;Piacentini, Luca;Clerici, Mario
载脂蛋白B mRNA编辑酶，催化多肽样3G（APOBEC 3G），一种人胞苷脱氨酶，是HIV复制的有效抑制剂。为了探索这种蛋白在调节体内HIV感染易感性中的可能作用，我们分析了HIV暴露血清阴性个体、HIV血清阳性患者和健康对照受试者中的APOBEC 3G表达。结果显示，APOBEC 3G的表达在外周血单核细胞（PBMC）-主要是CD 14（+）细胞-和HIV暴露血清阴性个体的宫颈组织中显著增加。较高的APOBEC 3G表达与PBMC对HIV-1（Ba-L）R5株体外感染的易感性降低相关。APOBEC 3G可能在调节体内对性传播HIV感染的易感性中起重要作用。
Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G), a human cytidine deaminase, is a potent inhibitor of HIV replication. To explore a possible role of this protein in modulating in vivo susceptibility to HIV infection, we analyzed APOBEC3G expression in HIV-exposed seronegative individuals, HIV-seropositive patients, and healthy control subjects. The results showed that the expression of APOBEC3G is significantly increased in peripheral blood mononuclear cells (PBMCs)-mainly CD14(+) cells-and in cervical tissues of HIV-exposed seronegative individuals. Higher APOBEC3G expression correlated with a reduced susceptibility of PBMCs to in vitro infection with the HIV-1(Ba-L) R5 strain. APOBEC3G could be important in modulating in vivo susceptibility to sexually transmitted HIV infection.