Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis.
Recent Advances in Diabetic Kidney Diseases: From Kidney Injury to Kidney Fibrosis.
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DOI：
10.3390/ijms222111857
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发表时间：
2021-11-01
影响因子：
5.6
通讯作者：
Lin CL
中科院分区：
文献类型：
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作者：
Hung PH;Hsu YC;Chen TH;Lin CL
糖尿病肾病（DKD）是慢性肾病和终末期肾病的主要原因。DKD的自然病程包括肾小球过度滤过、进行性白蛋白尿、估计肾小球滤过率下降，最终导致肾衰竭。已知DKD与高血糖引起的代谢变化相关，导致肾小球肥大、肾小球硬化和肾小管间质炎症和纤维化。高血压也被认为会导致程序性表观遗传修饰。然而，涉及DKD的发病和进展的详细机制仍然难以捉摸。本文就DKD发病机制的研究进展作一综述。
Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease. The natural history of DKD includes glomerular hyperfiltration, progressive albuminuria, declining estimated glomerular filtration rate, and, ultimately, kidney failure. It is known that DKD is associated with metabolic changes caused by hyperglycemia, resulting in glomerular hypertrophy, glomerulosclerosis, and tubulointerstitial inflammation and fibrosis. Hyperglycemia is also known to cause programmed epigenetic modification. However, the detailed mechanisms involved in the onset and progression of DKD remain elusive. In this review, we discuss recent advances regarding the pathogenic mechanisms involved in DKD.
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