A General Model of Ion Passive Transmembrane Transport Based on Ionic Concentration
A General Model of Ion Passive Transmembrane Transport Based on Ionic Concentration
复制标题
基于离子浓度的离子被动跨膜传输通用模型
DOI：
10.3389/fncom.2018.00110
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发表时间：
2019-01-22
影响因子：
3.2
通讯作者：
Liu, Shenquan
中科院分区：
文献类型：
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作者：
Wang, Vincent Qiqian;Liu, Shenquan
目前主流的神经计算是基于Hodgkin和Huxley在1952年提出的电模型，该模型的核心是离子通道控制的离子被动跨膜运输。然而，对离子通道进化史的研究表明，一些神经元离子通道早于神经元。因此，为了加深我们对神经元活动的理解，离子通道模型应该应用于其他细胞。将电生理实验的范围从神经扩展到肌肉，从动物扩展到植物，从后生动物扩展到原生动物，导致了一些离子通道的发现。此外，这些新发现的离子通道的性质太复杂，不能用现有的常见模型来描述。因此，本文提出了一种估算电场作用下离子分布的简便方法，并建立了一个基于离子浓度的离子被动跨膜转运通用模型，该模型简单，但能解释和模拟膜片钳实验中的复杂现象，适用于不同物种不同细胞中的不同离子通道，符合目前对离子通道的普遍认识。最后，我们设计了一系列的数学实验，并与在植物细胞、卵母细胞、心肌细胞、心肌细胞和神经细胞上进行的典型电生理实验的结果进行了比较，以验证该模型。
Current mainstream neural computing is based on the electricity model proposed by Hodgkin and Huxley in 1952, the core of which is ion passive transmembrane transport controlled by ion channels. However, studies on the evolutionary history of ion channels have shown that some neuronal ion channels predate the neurons. Thus, to deepen our understanding of neuronal activities, ion channel models should be applied to other cells. Expanding the scope of electrophysiological experiments from nerve to muscle, animal to plant, and metazoa to protozoa, has lead the discovery of a number of ion channels. Moreover, the properties of these newly discovered ion channels are too complex to be described by current common models. Hence this paper has presented a convenient method for estimating the distribution of ions under an electric field and established a general ionic concentration-based model of ion passive transmembrane transport that is simple but capable of explaining and simulating the complex phenomena of patch clamp experiments, is applicable to different ion channels in different cells of different species, and conforms to the current general understanding of ion channels. Finally, we designed a series of mathematical experiments, which we have compared with the results of typical electrophysiological experiments conducted on plant cells, oocytes, myocytes, cardiomyocytes, and neurocytes, to verify the model.