The difference in endocochlear and endolymphatic sac d.c. potentials in response to furosemide and canrenoate as diuretics
The difference in endocochlear and endolymphatic sac d.c. potentials in response to furosemide and canrenoate as diuretics
复制标题
耳蜗内和内淋巴囊的差异
DOI：
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发表时间：
2004
影响因子：
2.6
通讯作者：
S. Sakai
中科院分区：
文献类型：
--
作者：
N. Mori;N. Uozumi;K. Yura;S. Sakai
本实验观察了袢利尿剂呋塞米和醛固酮拮抗剂坎利酸对豚鼠耳蜗内电位（EP）和内淋巴囊电位（ESP）的影响。静脉输注20 min后，100 mg/kg剂量的呋塞米对ESP无显著影响。然而，该剂量使EP降至负水平。坎利酸300 mg/kg静注20 min后，EP无明显变化，但ESP降低。EP和ESP对利尿剂反应的差异表明内淋巴间隙中两种直流电位的起源不同。
SummaryWe investigated the effects of furosemide, a loop diuretic, and canrenoate, an aldosterone antagonist, on the endocochlear potential (EP) and the endolymphatic sac potential (ESP) in the guinea pig. Furosemide produced no significant change in the ESP at a dose of 100 mg/kg after an intravenous infusion for 20 min. However, this dose decreased the EP to a negative level. Canrenoate produced no significant change in the EP at an intravenous dose of 300 mg/kg for 20 min, but it did decrease the ESP. The differences in the EP and ESP in the repsonse to the diuretics indicate a dissimilarity of the origin of both d.c. potentials in the endolymphatic space.