Atom-economic macrocyclic amphiphile based on guanidinium-functionalized selenacrown ether acting as redox-responsive nanozyme
Atom-economic macrocyclic amphiphile based on guanidinium-functionalized selenacrown ether acting as redox-responsive nanozyme
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李波, 徐强强, 沉鑫, 潘铁正, 尚杰, 葛岩, 齐振辉, 基于胍功能化硒冠醚氧化还原响应纳米酶的原子经济大环两亲物
DOI：
10.1016/j.cclet.2022.108015
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发表时间：
2023-02-21
影响因子：
9.1
通讯作者：
Qi, Zhenhui
中科院分区：
文献类型：
--
作者：
Li, Bo;Xu, Qiangqiang;Qi, Zhenhui
自组装的控制对于超分子材料的制备具有重要意义，但如何以原子经济的方式控制大环两亲物的水合、响应性、尺寸、催化作用等仍然是一个巨大的挑战。本文提出的527 Da的低分子量的大环两亲化合物是通过利用含硒冠醚作为疏水基序与胍基团作为亲水部分一起制备的。所得的基于苯并[21]冠-7的大环两亲物在水中容易形成氧化还原响应性固体纳米颗粒，其可以进一步互连成表面皱纹图案，并表现出催化二硫键形成的纳米酶。目前的工作突出了巨大的潜力胍和硒的冠醚的功能组件的控制。(c)2023由Elsevier B. V.代表中国化学会和中国医学科学院药物研究所出版。
Control of self-assembly is significant to the preparation of supramolecular materials, but the control of hydration, responsiveness, dimension, catalysis of macrocyclic amphiphiles in an atom-economic manner is still a great challenge. The herein presented 527 Da low-molecular-weight macrocyclic amphiphile was fabricated by utilizing the selenium-containing crown ether as a hydrophobic motif together with guani-dinium group as the hydrophilic moiety. The resulting benzo[21]crown-7 based macrocyclic amphiphile readily forms a redox-responsive solid nanoparticles in water, which can further interconnect into wrin-kled pattern on-surface, as well as exhibits as a nanozyme for catalyzing disulfid bond formation. The present work highlights the great potential of guanidinium-and selenium-containing crown ethers for the control of functional assemblies. (c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.