How to very efficiently functionalize gold nanoparticles by "click'' chemistry
How to very efficiently functionalize gold nanoparticles by "click'' chemistry
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DOI：
10.1039/b812249k
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发表时间：
2008-01-01
影响因子：
4.9
通讯作者：
Astruc, Didier
中科院分区：
文献类型：
--
作者：
Boisselier, Elodie;Salmon, Lionel;Astruc, Didier
以前在非常有用的金纳米颗粒(AuNPs)的“点击”功能化中遇到的困难导致低产率，现在通过使用特定条件来克服：1：1水-THF介质，化学计量比CuSO(4)和抗坏血酸钠，在20℃的惰性气氛中，提供叠氮烷基硫酸酯-AuNPs与各种亲水性(含PEG)和疏水性(有机和有机金属)炔烃之间的定量“点击”反应。
Difficulties previously encountered in the very useful "click'' functionalization of gold nanoparticles (AuNPs) resulting in low yields are now overcome by using specific conditions: 1 : 1 water-THF medium, stoichiometric CuSO(4) and sodium ascorbate, inert atmosphere at 20 degrees C that provide quantitative "click'' reactions between azidoalkylthiolate-AuNPs with various hydrophilic (PEG-containing) and hydrophobic (organic and organometallic) alkynes.