Ozz-E3 ubiquitin ligase targets sarcomeric embryonic myosin heavy chain during muscle development.
Ozz-E3 ubiquitin ligase targets sarcomeric embryonic myosin heavy chain during muscle development.
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Ozz-E3 泛素连接酶在肌肉发育过程中靶向肌节胚胎肌球蛋白重链。
DOI：
10.1371/journal.pone.0009866
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发表时间：
2010-03-24
期刊：
影响因子：
3.7
通讯作者：
d'Azzo A
中科院分区：
文献类型：
--
作者：
Campos Y;Qiu X;Zanoteli E;Moshiach S;Vergani N;Bongiovanni A;Harris AJ;d'Azzo A
Muscle contractile proteins are expressed as a series of developmental isoforms that are in constant dynamic remodeling during embryogenesis, but how obsolete molecules are recognized and removed is not known. Ozz is a developmentally regulated protein that functions as the adaptor component of a RING-type ubiquitin ligase complex specific to striated muscle. Ozz−/− mutants exhibit defects in myofibrillogenesis and myofiber differentiation. Here we show that Ozz targets the rod portion of embryonic myosin heavy chain and preferentially recognizes the sarcomeric rather than the soluble pool of myosin. We present evidence that Ozz binding to the embryonic myosin isoform within sarcomeric thick filaments marks it for ubiquitination and proteolytic degradation, allowing its replacement with neonatal or adult isoforms. This unique function positions Ozz within a system that facilitates sarcomeric myosin remodeling during muscle maturation and regeneration. Our findings identify Ozz-E3 as the ubiquitin ligase complex that interacts with and regulates myosin within its fully assembled cytoskeletal structure.
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影响因子：
64.5
作者：
Hoppe, T;Cassata, G;Baumeister, R
通讯作者：
Baumeister, R
DOI：
10.1073/pnas.0707330105
发表时间：
2008-01-15
影响因子：
11.1
作者：
Du, Shao Jun;Li, Huiqing;Zhong, Yongwang
通讯作者：
Zhong, Yongwang
UNC-45伴侣通过秀丽隐杆线虫中的肌球蛋白降解介导了肌动蛋白降解。
影响因子：
7.8
作者：
Landsverk, Megan L;Li, Shumin;Hutagalung, Alex H;Najafov, Ayaz;Hoppe, Thorsten;Barral, Jose M;Epstein, Henry F
通讯作者：
Epstein, Henry F
影响因子：
11.4
作者：
Bois, PRJ;Grosveld, GC
通讯作者：
Grosveld, GC
DOI：
10.1083/jcb.200901052
发表时间：
2009-06-15
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cohen S;Brault JJ;Gygi SP;Glass DJ;Valenzuela DM;Gartner C;Latres E;Goldberg AL
通讯作者：
Goldberg AL