Autogenous bone with or without hydroxyapatite bone substitute augmentation in rat calvarium within a plastic cap
Autogenous bone with or without hydroxyapatite bone substitute augmentation in rat calvarium within a plastic cap
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DOI：
10.1016/j.oooo.2011.08.004
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发表时间：
2012-11-01
影响因子：
2.9
通讯作者：
Ito, Koichi
中科院分区：
文献类型：
--
作者：
Oginuma, Tsuyoshi;Sato, Shuichi;Ito, Koichi
目标。我们评估了自体骨（AB）和羟基磷灰石骨（HA）对于评估大鼠颅骨骨骼包膜外骨增量的效果。研究设计。暴露12只大鼠的颅盖，并在颅盖内放置2个塑料帽，其中含有AB和HA或单独AB。使用微型 CT (R_mCT) 拍摄塑料帽内的骨增量图像。组织学切片沿着与第 12 周时 R_mCT 图像所用的平面相同的平面进行切割。使用 BV 测量软件计算骨体积 (BV)。结果。实验位点和对照位点的 BV 均增加。新生成的组织在实验位点和对照位点之间没有显着差异；然而，与实验点相比，对照点的矿化组织明显更高。结论。结果表明HA和AB的组合具有生物相容性并且允许骨传导。 （Oral Surg Oral Med Oral Pathol Oral Radiol 2012；114（增补 5）：S107-S113）
Objectives. We evaluated the effect of autogenous bone (AB) and hydroxyapatite bone (HA) for the assessment of bone augmentation beyond the skeletal envelope in the rat calvarium.Study Design. The calvaria of 12 rats were exposed and 2 plastic caps were placed with AB and HA or AB alone in the calvarium. Images of bone augmentation within the plastic caps were taken using micro-CT (R_mCT). Histologic sections were cut along the same plane as those used for the R_mCT images at 12 weeks. Bone volume (BV) was calculated using BV-measuring software.Results. BV increased at both the experimental and control sites. The newly generated tissue did not significantly differ between the experimental and control sites; however, the mineralized tissue was significantly higher at control sites compared with experimental sites.Conclusions. The results indicate that the combination of HA and AB was biocompatible and allowed osteoconduction. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012; 114(suppl 5):S107-S113)