Skeletal (stromal) stem cells: An update on intracellular signaling pathways controlling osteoblast differentiation
Skeletal (stromal) stem cells: An update on intracellular signaling pathways controlling osteoblast differentiation
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DOI：
10.1016/j.bone.2014.07.028
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发表时间：
2015-01-01
期刊：
影响因子：
4.1
通讯作者：
Kassem, Moustapha
中科院分区：
文献类型：
--
作者：
Abdallah, Basem M.;Jafari, Abbas;Kassem, Moustapha
骨髓基质干细胞（BMSCs）是存在于骨髓基质中的一组多能干细胞，可分化为成骨细胞、软骨细胞和脂肪细胞。研究调节BMSC分化成骨细胞的信号通路是确定增强骨形成的药物靶点的策略。本文将讨论一些最近发现的调控分子的功能和作用的分子机制成骨细胞分化和骨形成：非经典的Notch信号分子Delta-like 1/前脂肪细胞因子1（Dlk 1/Pref-1），Wnt共受体Lrp 5和细胞内激酶。这篇文章是特刊的一部分，题为：干细胞和骨。(C)2014爱思唯尔公司All rights reserved.
Skeletal (marrow stromal) stem cells (BMSCs) are a group of multipotent cells that reside in the bone marrow stroma and can differentiate into osteoblasts, chondrocytes and adipocytes. Studying signaling pathways that regulate BMSC differentiation into osteoblastic cells is a strategy for identifying druggable targets for enhancing bone formation. This review will discuss the functions and the molecular mechanisms of action on osteoblast differentiation and bone formation; of a number of recently identified regulatory molecules: the non-canonical Notch signaling molecule Delta-like l/preadipocyte factor 1 (Dlk1/Pref-1), the Wnt co-receptor Lrp5 and intracellular kinases. This article is part of a Special Issue entitled: Stem Cells and Bone. (C) 2014 Elsevier Inc. All rights reserved.