Synthesis and biological evaluation of indolyl chalcones as antitumor agents
Synthesis and biological evaluation of indolyl chalcones as antitumor agents
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DOI：
10.1016/j.bmcl.2010.05.016
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发表时间：
2010-07-01
影响因子：
2.7
通讯作者：
Ito, Takeo
中科院分区：
文献类型：
--
作者：
Kumar, Dalip;Kumar, N. Maruthi;Ito, Takeo
合成了一系列吲哚查尔酮类化合物，并对它们的体外抗肿瘤活性进行了评价。化合物3b-d、3h、3j、3l、3m、4g和4j具有明显的细胞毒性，其中吲哚查尔酮3l和3m对Paca-2细胞的IC50值分别为0.03和0.09mU。(C)2010爱思唯尔有限公司。保留所有权利。
A series of indolyl chalcones were synthesized and evaluated in vitro for their anticancer activity against three human cancer cell lines. Compounds 3b-d, 3h, 3j, 3l, 3m, 4g, and 4j showed significant cytotoxicity, particularly, indolyl chalcones 3l and 3m were identified as the most potent and selective anticancer agents with IC50 values 0.03 and 0.09 mu M, against PaCa-2 cell line, respectively. (c) 2010 Elsevier Ltd. All rights reserved.