Zucker obese rats are sensitive to weight-reducing effect and insensitive to orexigenic effect by cold exposure
Zucker obese rats are sensitive to weight-reducing effect and insensitive to orexigenic effect by cold exposure
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Zucker肥胖大鼠对冷暴露的减肥作用敏感，但对食欲增加作用不敏感
DOI：
10.1016/s0306-4565(01)00064-x
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发表时间：
2001
影响因子：
2.7
通讯作者：
J. Tsujita
中科院分区：
文献类型：
--
作者：
S. Hori;K. Hori;T. Ishigaki;K. Koyama;M. Kaya;H. Takeda;J. Tsujita
将7周龄的雄性Wistar和Zucker（瘦型和肥胖型）大鼠分为三组：热适应（25°C持续11周）、冷适应（10°C持续11周）和去适应（10°C持续9周和25°C持续2周）组。与瘦大鼠相比，肥胖大鼠的体重（BM）增加率较低。冷适应的Wistar和Zucker瘦大鼠表现出更大的食物摄入量，相比，热适应的大鼠。暴露在寒冷中的肥胖大鼠的食物摄入量没有增加。肥胖大鼠对冷暴露的减肥作用敏感，对冷暴露的促食欲作用不敏感。
Male Wistar and Zucker (lean and obese) rats at 7 weeks of age were divided into three groups: warm-acclimated (25°C for 11 weeks), cold-acclimated (10°C for 11 weeks), and deacclimated (10°C for 9 weeks and 25°C for 2 weeks) groups. The rate of increase in body mass (BM) was lower in obese rats as compared to lean rats. Cold-acclimated Wistar and Zucker lean rats exhibited greater food intake, compared to warm-acclimated rats. Food intake did not increase in obese rats exposed to cold. Obese rats are sensitive to weight-reducing effect and insensitive to the orexigenic effect by cold exposure.