Association of HLA-DP/DQ, STAT4 and IL-28B variants with HBV viral clearance in Tibetans and Uygurs in China
Association of HLA-DP/DQ, STAT4 and IL-28B variants with HBV viral clearance in Tibetans and Uygurs in China
复制标题
中国藏族和维吾尔族 HLA-DP/DQ、STAT4 和 IL-28B 变异与 HBV 病毒清除的关系
DOI：
10.1111/liv.12643
复制
发表时间：
2015-03-01
影响因子：
6.7
通讯作者：
Wang, Lanlan
中科院分区：
文献类型：
--
作者：
Liao, Yun;Cai, Bei;Wang, Lanlan
背景与目的多项全基因组关联研究表明，HLA-DP/DQ、STAT4和IL-28B与肝脏疾病相关。但由于种群异质性，不同的种族会有不同的致病多态性。7个单核苷酸多态性（SNP）进行基因分型。61, 95% ci =0.46-0.82；rs9277535， OR=0.56, 95% CI=0.41-0.75；rs7453920， OR=0.64, 95%CI=0.47-0.85；维吾尔族，rs3077， OR=0.48, 95% CI=0.24-0.96；rs9277535， OR=0.43, 95% CI=0.20-0.91；rs7453920， OR=0.62, 95% CI=0.39-0.99)，而在两种种族中IL-28B与HBV自然清除率之间均未观察到显著相关性（P < 0.05）。76, 95% ci =0.58-0.99)。STAT4 rs7574865 GG基因型在基因型C病毒感染患者中出现频率更高（P=0.005）。此外，维吾尔族HLA-DP/DQ保护性等位基因的频率更高（rs3077为72.5%，rs9277535为76.6%，rs3077为26.7%，rs9277535为52.5%，rs7453920为18.5%）
Background & AimsSeveral genome-wide association studies have revealed that HLA-DP/DQ, STAT4 and IL-28B associated with liver diseases. But because of population heterogeneity, different races would have different causative polymorphisms. Therefore, in this study, we included Chinese Tibetans and Uygurs to examine the roles of these genes on HBV natural clearance.MethodsA total of 1341 subjects including 908 Tibetans and 433 Uygurs were recruited. Seven single nucleotide polymorphisms (SNP) were genotyped.ResultsHLA-DP/DQ polymorphisms associated with HBV natural clearance in both ethnicities (Tibetans, rs3077, OR=0.61, 95% CI=0.46-0.82; rs9277535, OR=0.56, 95% CI=0.41-0.75; rs7453920, OR=0.64, 95%CI=0.47-0.85; Uygurs, rs3077, OR=0.48, 95% CI=0.24-0.96; rs9277535, OR=0.43, 95% CI=0.20-0.91; rs7453920, OR=0.62, 95% CI=0.39-0.99), whereas no significant association was observed between IL-28B with HBV natural clearance in neither ethnicities (P>0.05). STAT4 rs7574865 seemed to be Tibetan specific in HBV natural clearance (OR=0.76, 95% CI=0.58-0.99). Moreover, in Tibetan patients, HLA-DQ rs7453920 GG had a higher frequency in HBeAg positive patients (P=0.032) and STAT4 rs7574865 GG genotype appeared more frequently in Genotype C virus infected patients (P=0.005). In addition, Uygurs have higher frequencies of HLA-DP/DQ protective alleles (72.5% for rs3077, 76.6% for rs9277535 and 26.8% for rs7453920) than Tibetans (51.7% for rs3077, 52.5% for rs9277535 and 18.5% for rs7453920)(all P