Somatosensory cortical plasticity in adult humans revealed by magnetoencephalography.
Somatosensory cortical plasticity in adult humans revealed by magnetoencephalography.
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DOI：
10.1073/pnas.90.8.3593
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发表时间：
1993-04
影响因子：
11.1
通讯作者：
A. Mogilner;J. Grossman;U. Ribary;M. Joliot;Jens Volkmann;Dave Rapaport;R. Beasley;R. Llinás
中科院分区：
文献类型：
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作者：
A. Mogilner;J. Grossman;U. Ribary;M. Joliot;Jens Volkmann;Dave Rapaport;R. Beasley;R. Llinás
在成年哺乳动物身上的微电极记录清楚地表明，在周围神经损伤和功能改变后，体感皮层映射图发生了重组；然而，这种重组从未在人类中被直接证明。利用脑磁图，我们已经能够以高空间精度显示正常人手部区域的体位组织。研究对象为两名成人，他们在手术分离(并指)手术前后检测到躯体感觉皮质的可塑性。术前地图显示缩小的和非体位的手部图像。在手术后的几周内，皮质重组发生在3-9毫米的距离上是明显的，这与他们分离的手指的新的功能状态有关。相比之下，在两名感觉转移失败的受试者中，在移植神经血管皮岛状皮瓣进行拇指感觉重建的几个月后，没有观察到躯体感觉图的改变。
Microelectrode recordings in adult mammals have clearly demonstrated that somatosensory cortical maps reorganize following peripheral nerve injuries and functional modifications; however, such reorganization has never been directly demonstrated in humans. Using magnetoencephalography, we have been able to demonstrate the somatotopic organization of the hand area in normal humans with high spatial precision. Somatosensory cortical plasticity was detected in two adults who were studied before and after surgical separation of webbed fingers (syndactyly). The presurgical maps displayed shrunken and nonsomatotopic hand representations. Within weeks following surgery, cortical reorganization occurring over distances of 3-9 mm was evident, correlating with the new functional status of their separated digits. In contrast, no modification of the somatosensory map was observed months following transfer of a neurovascular skin island flap for sensory reconstruction of the thumb in two subjects in whom sensory transfer failed to occur.