The Sparing Effect of Low-Dose Esmolol on Sevoflurane during Laparoscopic Gynaecological Surgery
The Sparing Effect of Low-Dose Esmolol on Sevoflurane during Laparoscopic Gynaecological Surgery
复制标题
小剂量艾司洛尔对七氟醚在腹腔镜妇科手术中的节约作用
DOI：
10.1177/147323001103900529
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发表时间：
2011
影响因子：
1.6
通讯作者：
J. Lee
中科院分区：
文献类型：
--
作者：
Y. Moon;W. Hwang;H. Koh;J. Min;J. Lee
这项双盲、随机、安慰剂对照研究评估了 2009 年 12 月至 2010 年 5 月期间 54 名患者在腹腔镜妇科手术期间艾司洛尔对七氟醚的节约效果。确定了维持充分麻醉所需的七氟醚浓度。患者接受 0.5 mg/kg 艾司洛尔静脉负荷剂量，然后每分钟输注 30 μg/kg 或等体积的生理盐水（安慰剂）。手术期间，每 5 分钟调整七氟醚的输入浓度，以将收缩压维持在基线的 15% 范围内，并将双频谱指数维持在 50-60。输注艾司洛尔导致平均七氟醚输入浓度降低 18.2%。接受艾司洛尔治疗的患者可以较早地从麻醉后监护室出院，并且芬太尼的平均剂量也较低。总之，术中输注艾司洛尔减少了七氟烷的需求量和术后芬太尼的使用量。
This double-blind, randomized, placebocontrolled study evaluated the sparing effect of esmolol on sevoflurane during laparoscopic gynaecological surgery in 54 patients between December 2009 and May 2010. The concentration of sevoflurane required to maintain adequate anaesthesia was determined. Patients received either a 0.5 mg/kg esmolol intravenous loading dose followed by infusion of 30 μg/kg per min or an identical volume of normal saline (placebo). During surgery the input concentration of sevoflurane was adjusted every 5 min to maintain systolic blood pressure within 15% of baseline and bispectral index at 50–60. Infusion of esmolol resulted in an 18.2% decrease in mean sevoflurane input concentration. Patients receiving esmolol had an earlier discharge from the postanaesthetic care unit and a lower mean fentanyl dose. In conclusion, intraoperative esmolol infusion decreased both the requirement for sevoflurane and postoperative administration of fentanyl.
使用源自最大心室功率的单一心跳指数对挥发性麻醉剂引起的心肌收缩力抑制进行定量。
影响因子：
2.8
作者：
Pagel,PS;Nijhawan,N;Warltier,DC
通讯作者：
Warltier,DC