Hemodynamic signature of breast cancer under fractional mammographic compression using a dynamic diffuse optical tomography system
Hemodynamic signature of breast cancer under fractional mammographic compression using a dynamic diffuse optical tomography system
复制标题
DOI：
10.1364/boe.4.002911
复制
发表时间：
2013-12-01
影响因子：
3.4
通讯作者：
Isakoff, Steven J.
中科院分区：
文献类型：
--
作者：
Carp, Stefan A.;Sajjadi, Amir Y.;Isakoff, Steven J.
近红外动态扩散光学断层扫描测量乳腺血流动力学在部分乳腺摄影压缩提供了一种新的对比机制，检测乳腺癌和监测化疗。压缩期间的组织粘弹松弛导致压缩力缓慢降低，并揭示健康组织和病变组织之间的生物力学和代谢差异。我们测量了22例计划接受新辅助化疗的II期和III期乳腺癌患者在25-35 N压缩过程中血红蛋白浓度的绝对值和时间演变。17例患者被纳入组分析（平均肿瘤大小3.2 cm，范围：1.3-5.7 cm）。我们观察到，早在压迫期30秒时，肿瘤区域与健康组织的总血红蛋白和氧合血红蛋白以及血红蛋白氧饱和度就出现了统计学显著差异性降低。血流动力学对比可能是由较高的肿瘤硬度和不同的粘弹性松弛速率以及较高的肿瘤氧代谢速率驱动的。(C)2013年美国光学学会
Near infrared dynamic diffuse optical tomography measurements of breast hemodynamics during fractional mammographic compression offer a novel contrast mechanism for detecting breast cancer and monitoring chemotherapy. Tissue viscoelastic relaxation during the compression period leads to a slow reduction in the compression force and reveals biomechanical and metabolic differences between healthy and lesion tissue. We measured both the absolute values and the temporal evolution of hemoglobin concentration during 25-35 N of compression for 22 stage II and III breast cancer patients scheduled to undergo neoadjuvant chemotherapy. 17 patients were included in the group analysis (average tumor size 3.2 cm, range: 1.3-5.7 cm). We observed a statistically significant differential decrease in total and oxy-hemoglobin, as well as in hemoglobin oxygen saturation in tumor areas vs. healthy tissue, as early as 30 seconds into the compression period. The hemodynamic contrast is likely driven by the higher tumor stiffness and different viscoelastic relaxation rate, as well as the higher tumor oxygen metabolism rate. (C) 2013 Optical Society of America