Temporal differences in praziquantel- and oxamniquine-induced tegumental damage to adult Schistosoma mansoni: Implications for drug-antibody synergy
Temporal differences in praziquantel- and oxamniquine-induced tegumental damage to adult Schistosoma mansoni: Implications for drug-antibody synergy
复制标题
DOI：
10.1017/s0031182000065069
复制
发表时间：
1996-01-01
期刊：
影响因子：
2.4
通讯作者：
Wharton, GA
中科院分区：
文献类型：
--
作者：
Fallon, PG;Fookes, RE;Wharton, GA
本文报道了吡喹酮和奥曲喹对曼氏血吸虫成虫体表作用的时间效应。吡喹酮治疗后1小时内，药物引起的皮层损伤、表面抗原暴露和宿主抗体附着迅速发生。经奥曲喹处理的蠕虫需要4-8天才能出现这些效果。这两种药物对蠕虫表面的损伤程度和部位不同。给药2种不同的多特异性兔血清与药物显着增加吡喹酮的疗效时，与药物给药，但不给药后6-9天。相比之下，当与药物一起给药时，仅1种血清与奥曲喹具有协同作用，并且当在药物治疗后6-9天给药时，两种血清均具有协同作用。本文还讨论了药物对蠕虫的免疫杀伤作用。
A temporal study of the effects on the tegument of Schistosoma mansoni adult worm following in vivo praziquantel and oxamniquine treatment was performed. Drug-induced damage to the tegument, exposure of surface antigens and attachment of host antibody occurred rapidly, within 1 h, following praziquantel treatment. Oxamniquine-treated worms required 4-8 days for these effects to be apparent. The 2 drugs differed in the degree and sites of damage on the worm surface. The administration of 2 different polyspecific rabbit sera with drug significantly increased the efficacy of praziquantel when administered with the drug, but not when given 6-9 days after drug treatment. In contrast, only 1 serum was synergistic with oxamniquine when administered with drug and both sera were synergistic when given 6-9 days after drug treatment. The effect of immune killing of drug-treated worms is discussed.