Polygenic Scores for Differential Susceptibility to Emotional Symptoms Predict Response to Cbt in Child Anxiety
Polygenic Scores for Differential Susceptibility to Emotional Symptoms Predict Response to Cbt in Child Anxiety
复制标题
对情绪症状的不同易感性的多基因评分可预测儿童焦虑中对 Cbt 的反应
DOI：
10.1016/j.euroneuro.2016.09.606
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发表时间：
2017
影响因子：
5.6
通讯作者：
Eley T
中科院分区：
文献类型：
--
作者：
Eley T
背景差异相容性假说认为，某些遗传变异缓和了消极和积极环境对心理健康的影响，因此可能是心理治疗反应的重要预测因子。然而，迄今为止，这些变体的鉴定仅限于预选的候选基因。在这项研究中，我们扩展了差异易感性假说从一个候选基因到全基因组的方法，以测试是否多基因得分的环境敏感性预测响应认知行为疗法（CBT）在儿童焦虑disorders.MethodsWe确定变异与环境敏感性使用一种新的方法，其中内对变异的情绪问题，在1，026对同卵双生子进行了检查，作为对基因型的函数。我们创建了一个多基因的分数的环境敏感性的基础上的全基因组的研究结果和测试的分数作为一个主持人的父母对情绪问题的1,406名儿童和个人，团体和简短的父母为主导的CBT在973名儿童焦虑disorders.ResultsThe多基因的分数显着缓和的影响，父母对情绪问题和治疗的效果。个人得分高，个人CBT比组CBT或简短的家长领导的CBT（缓解率：70.9，55.5和41.6%，分别）。然而，如果重复，他们表明，具有最大环境敏感性的个人可能更容易在不利的环境中出现情绪问题，但也从最密集的治疗中获益更多。
BackgroundThe differential susceptibly hypothesis suggests that certain genetic variants moderate the effects of both negative and positive environments on mental health and may therefore be important predictors of response to psychological treatments. Nevertheless, the identification of such variants has so far been limited to preselected candidate genes. In this study we extended the differential susceptibility hypothesis from a candidate gene to a genome-wide approach to test whether a polygenic score of environmental sensitivity predicted response to cognitive behavioural therapy (CBT) in children with anxiety disorders.MethodsWe identified variants associated with environmental sensitivity using a novel method in which within-pair variability in emotional problems in 1,026 monozygotic twin pairs was examined as a function of the pairs' genotype. We created a polygenic score of environmental sensitivity based on the whole-genome findings and tested the score as a moderator of parenting on emotional problems in 1,406 children and response to individual, group and brief parent-led CBT in 973 children with anxiety disorders.ResultsThe polygenic score significantly moderated the effects of parenting on emotional problems and the effects of treatment. Individuals with a high score responded significantly better to individual CBT than group CBT or brief parent-led CBT (remission rates: 70.9, 55.5 and 41.6%, respectively).ConclusionsPending successful replication, our results should be considered exploratory. Nevertheless, if replicated, they suggest that individuals with the greatest environmental sensitivity may be more likely to develop emotional problems in adverse environments but also benefit more from the most intensive types of treatment.