The 1987 Catalog of Mapped Genes and Report of the Nomenclature Committee (Part 1 of 4)
The 1987 Catalog of Mapped Genes and Report of the Nomenclature Committee (Part 1 of 4)
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1987 年映射基因目录和命名委员会报告（第 1 部分，共 4 部分）
DOI：
10.1159/000132472
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发表时间：
1987
影响因子：
1.7
通讯作者：
T. Shows
中科院分区：
文献类型：
--
作者：
P. McAlpine;N. Cong;C. Boucheix;A. Pakstis;R. Douté;T. Shows
现实的期望是人类基因组很快就会被绘制出来。基于不同技术的几种地图将会产生；例如，人类24条不同染色体的物理-细胞遗传学图谱、连锁图谱、远程限制性内切酶图谱和核苷酸序列图谱。这些地图虽然反映了基于方法的差异，但都产生互补和共线性地图。链接和物理地图需要相同的命名法来识别位点符号。远程限制图、cosmid图和序列图可能需要不同的命名法来识别它们的组成部分。然而，使用不同方法开发的地图最终将与已绘制的DNA标记和克隆基因合并，最有可能用作识别相对较大的DNA片段的标志。对这些开发的命名考虑将是未来的一个主要主题。本次研讨会中，除DNA片段和脆弱位点外，所有基因标记及其符号均由该委员会评估和更新。人类基因标记目录见表1，并按基因符号的字母顺序列出标记。这一信息来源于染色体委员会的报告、HGM9的摘要和我们之前绘制的基因目录（McAlpine et al., 1985）。仅包括在本次和以往研讨会上获得批准的测绘数据的位点；匿名DNA片段和脆弱位点已由各自的委员会制成表格。表二按字母顺序列出了已映射的基因标记名称。遗传标记的符号遵循爱丁堡研讨会（HGM5）和巴黎研讨会（HGM9）批准的指南（Shows等人，1979；Shows等人，HGM9）。这些人类基因定位研讨会批准的指导方针被敦促遵循，以建立一个有序的基因命名和编目系统。
There is the realistic expectation that the human genome will be mapped soon. Several maps based on different technologies will result; for example, the physical-cytogenetic map, the linkage map, the long-range restriction map and the nucleotide sequence map of each of the 24 different human chromosomes. These maps, while reflecting differences based on methodology, all yield complementary and co-linear maps. The linkage and physical maps require the same nomenclature for identifying locus symbols. The long-range restriction maps, cosmid maps and sequence maps may require different nomenclature to identify their components. Nevertheless, the maps developed using different approaches will eventually merge with mapped DNA markers and cloned genes most likely being used as sign posts to identify relatively large DNA segments. Nomenclature considerations for these developments will be a major topic for the future. For this workshop, all gene markers and their symbols, excluding DNA segments and fragile sites, were evaluated and updated by this committee. The catalog of human gene markers is presented in Table I and lists markers in alphabetical order by gene symbol. This information is derived from chromosome committee reports, HGM9 abstracts and our previous catalog of mapped genes (McAlpine et al., 1985). Only loci for which mapping data have been approved at this and previous workshops have been included; anonymous DNA segments and fragile sites have been tabulated by their respective committees. Table II lists mapped gene marker names in alphabetical order. Symbols for the genetic markers follow the guidelines approved at the Edinburgh Workshop (HGM5) and again at the Paris Workshop (HGM9)(Shows et al., 1979; Shows et al., HGM9). It is urged that these guidelines approved by Human Gene Mapping Workshops be followed for an orderly system of naming and cataloging genes.