Preparation and evaluation of poly (D, L-lactic acid) (PLA) or D, L-lactide/glycolide copolymer (PLGA) microspheres with estradiol.
Preparation and evaluation of poly (D, L-lactic acid) (PLA) or D, L-lactide/glycolide copolymer (PLGA) microspheres with estradiol.
复制标题
雌二醇聚（D，L-乳酸）（PLA）或D，L-丙交酯/乙交酯共聚物（PLGA）微球的制备和评价。
DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
Z. Feng
中科院分区：
文献类型：
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作者：
Z. Xinteng;P. Weisan;Z. Ruhua;Z. Feng
以PLA/PLGA为生物可降解、生物相容性好的载体，实现雌二醇的缓释。采用溶剂蒸发法制备了E2/PLA微球，考察了水相中PVA浓度、有机相中PLA浓度、搅拌速度、O/W体积比、E2/PLA质量比、聚合物种类和分子量等因素对微球性能和体外释药行为的影响。
PLA/PLGA was used for biodegradable and biocompatible carriers to achieve sustained release of estradiol. Microspheres were formed by an emulsification-solvent evaporation method, and then their properties and in vitro drug release behavior were examined including amongst others the effects of the concentration of PVA in the aqueous phase, the concentration of PLA in the organic phase, the stirring speed, the volume ratio of O/W, the weight ratio of E2/PLA fed, and the type and molecular weight of the polymers.