Facile two-step synthesis of 3-substituted indazoles using diazo(trimethylsilyl)methylmagnesium bromide
Facile two-step synthesis of 3-substituted indazoles using diazo(trimethylsilyl)methylmagnesium bromide
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DOI：
10.1039/b907796k
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发表时间：
2009-01-01
影响因子：
3.2
通讯作者：
Aoyama, Toyohiko
中科院分区：
文献类型：
--
作者：
Hari, Yoshiyuki;Sone, Ryosuke;Aoyama, Toyohiko
重氮（三甲基硅基）甲基溴化镁容易与各种酮和醛反应，得到相应的2-重氮-（2-三甲基硅基）乙醇。这些被有效地转化为吲唑轴承羟甲基单元在3-位通过分子间[3+2]环加成与苄炔。
Diazo(trimethylsilyl)methylmagnesium bromide readily reacted with various ketones and aldehydes to give the corresponding 2-diazo-(2-trimethylsilyl)ethanols. These were efficiently converted to indazoles bearing hydroxymethyl units at the 3-position by intermolecular [3+2] cycloaddition with benzynes.