PLASMA AND CEREBROSPINAL-FLUID CONCENTRATIONS OF PARACETAMOL AFTER A SINGLE INTRAVENOUS DOSE OF PROPACETAMOL
PLASMA AND CEREBROSPINAL-FLUID CONCENTRATIONS OF PARACETAMOL AFTER A SINGLE INTRAVENOUS DOSE OF PROPACETAMOL
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DOI：
10.1111/j.1365-2125.1992.tb04112.x
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发表时间：
1992-07-01
影响因子：
3.4
通讯作者：
GAUCHER, A
中科院分区：
文献类型：
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作者：
BANNWARTH, B;NETTER, P;GAUCHER, A
由于扑热息痛的解热作用和可能的镇痛作用至少部分是中枢调节的，因此我们测定了43例神经根压迫痛患者的血浆和脑脊液中扑热息痛浓度。每个受试者都接受了一次简短的静脉注射。输注2克扑热息痛，这是一种前体药物，在7分钟内被水解为扑热息痛。每例患者每隔20分钟至12小时同时采集血样和脑脊液标本，脑脊液药物浓度在4小时达到最大值，随后浓度超过血浆浓度。由混合数据计算的扑热息痛在血浆中的消除半衰期(2.4h)比在脑脊液中的消除半衰期(3.2h)短。脑脊液中扑热息痛的时程可能与其镇痛作用的时程平行。
Since the antipyretic and probably the analgesic effects of paracetamol are, at least in part, centrally mediated, its plasma and cerebrospinal fluid (CSF) concentrations were measured in 43 patients with nerve-root compression pain. Each subject was given a short i.v. infusion of 2 g propacetamol, a prodrug which is hydrolysed to paracetamol within 7 min. Single blood and CSF samples were drawn concomitantly in each patient at intervals between 20 min and 12 h. Maximum CSF drug concentrations were observed at the 4th hour, subsequent concentrations exceeding those in plasma. The elimination half-life of paracetamol calculated from pooled data was shorter in plasma (2.4 h) than in CSF (3.2 h). The time-course of paracetamol in CSF may parallel that of analgesic effect.