The associations between serum perfluorinated chemicals and thyroid function in adolescents and young adults
The associations between serum perfluorinated chemicals and thyroid function in adolescents and young adults
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DOI：
10.1016/j.jhazmat.2012.10.049
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发表时间：
2013-01-15
影响因子：
13.6
通讯作者：
Su, Ta-Chen
中科院分区：
文献类型：
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作者：
Lin, Chien-Yu;Wen, Li-Li;Su, Ta-Chen
多年来，全氟化学品 (PFC) 已广泛应用于全球各种产品中。然而，PFCs对甲状腺功能的影响尚未明确。我们招募了 567 名受试者（年龄 12-30 岁），研究对象为童年时期尿液分析异常的青少年和年轻人，以确定血清 PFC 水平与血清游离甲状腺素 (T4) 和促甲状腺激素 (TSH) 水平之间的关系。全氟辛酸（PFOA）、全氟辛烷磺酸（PFOS）、全氟壬酸（PFNA）和全氟十一烷酸（PFUA）的几何平均值和几何标准偏差浓度分别为2.67（2.96）ng/ml、7.78（2.42）ng/ml、1.01（3.48）ng/ml和5.81（2.92）ng/ml。分别为 ng/ml。不同类别的 PFOA、PFOS 和 PFUA 的游离 T4 和 TSH 水平差异不显着。控制混杂因素后，多元线性回归分析显示，不同 PFNA 类别（第 90 个百分位数）的平均血清游离 T4 水平显着增加（完整模型中趋势 P = 0.012）。在分层分析中，PFNA 和游离 T4 之间的关联在 20-30 岁年龄组的男性受试者、主动吸烟者和体重指数较高的受试者中更为显着。青少年和年轻人的 PFNA 血清浓度与血清游离 T4 水平相关。 (c) 2012 Elsevier B.V. 保留所有权利。
Perfluorinated chemicals (PFCs) have been widely used in a variety of products worldwide for years. However, the effect of PFCs on thyroid function has not yet been clearly defined. We recruited 567 subjects (aged 12-30 years) in a population-based cohort of adolescents and young adults with abnormal urinalysis in the childhood to determine the relationship between serum level of PFCs and the levels of serum free thyroxine (T4) and thyroid stimulating hormone (TSH). The geometric means and geometric standard deviation concentrations of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUA) were 2.67 (2.96) ng/ml, 7.78 (2.42) ng/ml, 1.01 (3.48) ng/ml and 5.81 (2.92) ng/ml, respectively. Differences in the levels of free T4 and TSH across different categories of PFOA, PFOS and PFUA were insignificant. After controlling for confounding factors, multiple linear regression analyses revealed mean serum level of free T4 increased significantly across categories (90th percentiles) of PFNA (P for trend =0.012 in the full model). The association between PFNA and free T4 was more significant in male subjects in age group 20-30, active smokers and in those with higher body mass index in stratified analysis. Serum concentrations of PFNA were associated with serum free T4 levels in adolescents and young adults. (c) 2012 Elsevier B.V. All rights reserved.