Effect of in utero growth retardation on lung function at follow-up of prematurely born infants
Effect of in utero growth retardation on lung function at follow-up of prematurely born infants
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DOI：
10.1183/09031936.04.00060304
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发表时间：
2004-11-01
影响因子：
24.3
通讯作者：
Cheeseman, P
中科院分区：
文献类型：
--
作者：
Greenough, A;Yuksel, B;Cheeseman, P
本研究的目的是确定患有宫内生长迟缓（IUGR）的早产儿是否比出生时体重与胎龄相适应（阿加）的早产儿有更严重的肺功能异常。总共有31名婴儿患有IUGR，出生时小于胎龄（SGA）。在出生后10（6-24）个月的中位年龄时测量功能性残气量和气道阻力（Raw）。比气道传导率（sGaw）由胸腔气体量和Raw计算。SGA儿童出生时胎龄大于阿加儿童，且测试时体重低于AGA儿童。SGA和阿加儿童的Raw和sGaw不同。回归分析表明，肺容量显着相关的体重在测试中，Raw相关的IUGR，母亲吸烟和支气管肺发育不良，sGaw的母亲smoking.In结论，这些结果表明，早产儿谁遭受宫内生长迟缓可能是在后续的肺功能受损的风险增加。
The aim of the study was to determine if prematurely born children who had suffered intra-uterine growth retardation (IUGR) had more severe lung function abnormalities than those born an appropriate weight for gestational age (AGA).Analysis of the lung function results of 119 infants (median (range) gestational age of 30 (23-35) weeks) was undertaken. In total, 31 of the infants had suffered IUGR and were born small for gestational age (SGA). Functional residual capacity and airways resistance (Raw) were measured at a median post-natal age of 10 (6-24) months. Specific airway conductance (sGaw) was calculated from thoracic gas volume and Raw.The SGA children were born at a greater gestational age and had a lower body weight at testing than the AGA children. Raw and sGaw differed between the SGA and AGA children. Regression analysis demonstrated that lung volumes were significantly related to body weight at testing, Raw was related to IUGR, maternal smoking and bronchopulmonary dysplasia, and sGaw to maternal smoking.In conclusion, these results suggest that prematurely born infants who have suffered intra-uterine growth retardation may be at increased risk of impaired lung function at follow-up.