Detection of nonlinear interactions of EEG alpha waves in the brain by a new coherence measure and its application to epilepsy and anti-epileptic drug therapy.
Detection of nonlinear interactions of EEG alpha waves in the brain by a new coherence measure and its application to epilepsy and anti-epileptic drug therapy.
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DOI：
10.1142/s0129065711002754
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发表时间：
2011-04
影响因子：
8
通讯作者：
Hinich MJ
中科院分区：
文献类型：
--
作者：
Sherman D;Zhang N;Garg S;Thakor NV;Mirski MA;White MA;Hinich MJ
在皮层和丘脑建立的脑电和场电位节律可能适应癫痫的传播。本文研究了戊四氮(PTZ)癫痫发作过程中丘脑与皮质的相互作用。AED在PTZ惊厥给药前给药。我们用一种名为交叉双相干增益或BISCOH的新测量方法来跟踪这种丘脑-大脑皮层的联系。这个量使我们可以用一种纯粹的高阶谱方法来测量光谱相干性。BISCOH能够跟踪在记录的EEG中特定频率的非线性的形成。BISCOH10和12.5赫兹的低α波谐振量在电刺激后显著增加(P<；0.02和P<；0.007)。在ESM治疗后，在这些频率下，传统的相干性没有显示出丘脑-皮质耦合的明显和显著的变化，相反，在5赫兹显示了变化。这种皮层节律的增加是AED治疗后丘脑-皮质系统产生谐波或形成新频率的证据。BISCOH可能成为解开药物治疗或电刺激引起的神经电调制引起的一致性变化的有力工具。
EEG and field potential rhythms established in the cortex and thalamus may accommodate the propagation of seizures. This article describes the interaction between thalamus and cortex during pentylenetetrazol (PTZ) seizures in rats with and without prior treatment with ethosuximide (ESM), a well-known antiepileptic drug (AED) that raises the threshold for seizures, was given before PTZ. The AED was given before PTZ convulsant administration. We track this thalamo-cortical association with a novel measure we have called the cross-bicoherence gain, or BISCOH. This quantity allows us to measure the spectral coherence in a purely higher order spectralmethodology. BISCOH is able to track the formation of nonlinearities at specific frequencies in the recorded EEG. BISCOH showed a strong increase in low alpha wave harmonic generationat 10 and 12.5 Hz after ESM treatment (p < 0.02 and p < 0.007, respectively). Conventional coherence failed to show distinctive and significant changes in thalamo-cortical coupling after ESM treatment at those frequencies and instead showed changes at 5 Hz. This rise in cortical rhythms is evidence of harmonic generation or new frequency formation in the thalamo-cortical system with AED therapy. BISCOH could become a powerful tool in unraveling changes in coherence due to neuroelectric modulation resulting from drug treatment or electrical stimulation.