Iron and manganese transport in mammalian systems.
Iron and manganese transport in mammalian systems.
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DOI：
10.1016/j.bbamcr.2020.118890
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Knutson MD
中科院分区：
文献类型：
--
作者：
Liu Q;Barker S;Knutson MD
近年来的研究已经显着扩大，完善，并重新定义了转运蛋白和其他蛋白质参与铁和锰（Mn）的运输和体内平衡。在这篇综述中，我们讨论了铁和锰的运输，重点是膜转运蛋白和相关蛋白质的作用，最近的文献亮点。研究从积极控制全身铁或锰稳态的主要器官、组织和细胞类型的Vantage角度考虑，重点是直接测量体内金属转运或使用基因敲除小鼠模型进行牵连的研究。还提供了全身和细胞铁和锰稳态的概述，以提供关键转运蛋白的生理背景，并强调它们如何参与每种金属的摄取、细胞内运输和外排。铁和锰运输的重要的相似性和差异，并确定了未来的研究机会和挑战。
Studies in recent years have significantly expanded, refined, and redefined the repertoire of transporters and other proteins involved in iron and manganese (Mn) transport and homeostasis. In this review, we discuss highlights of the recent literature on iron and Mn transport, focusing on the roles of membrane transporters and related proteins. Studies are considered from the vantage point of main organs, tissues, and cell types that actively control whole-body iron or Mn homeostasis, with emphasis on studies in which in vivo metal transport was measured directly or implicated by using knockout mouse models. Overviews of whole-body and cellular iron and Mn homeostasis are also provided to give physiological context for key transporters and to highlight how they participate in the uptake, intracellular trafficking, and efflux of each metal. Important similarities and differences in iron and Mn transport are noted, and future research opportunities and challenges are identified.
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