X-chromosome inactivation and escape.
X-chromosome inactivation and escape.
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DOI：
10.1007/s12041-015-0574-1
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发表时间：
2015-12
影响因子：
1.5
通讯作者：
Berletch JB
中科院分区：
文献类型：
--
作者：
Disteche CM;Berletch JB
玛丽·里昂 (Mary Lyon) 于 1961 年发现 X 染色体失活会导致雌性哺乳动物中一条 X 染色体随机沉默。这篇评论献给去年去世的玛丽·里昂。她预测了 X 失活的许多特征，例如 X 失活中心的存在、L1 元件在沉默传播中的作用以及逃避 X 失活的基因的存在。从她在这里发表的作品开始，我们总结了该领域的进展。
X-chromosome inactivation, which was discovered by Mary Lyon in 1961 results in random silencing of one X chromosome in female mammals. This review is dedicated to Mary Lyon, who passed away last year. She predicted many of the features of X inactivation, for e.g., the existence of an X inactivation center, the role of L1 elements in spreading of silencing and the existence of genes that escape X inactivation. Starting from her published work here we summarize advances in the field.