Adult T-cell leukemia in Japan
Adult T-cell leukemia in Japan
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DOI：
10.1097/00042560-199600001-00004
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发表时间：
1996-01-01
期刊：
影响因子：
--
通讯作者：
Yamaguchi, K
中科院分区：
文献类型：
--
作者：
Takatsuki, K;Matsuoka, M;Yamaguchi, K
Adult T-cell leukemia (ATL) was first reported in Japan, where it has a high incidence in the southwestern region. The retrovirus, human T-lymphotropic virus type I (HTLV-I), is found to be the causative agent of ATL. In ATL-endemic areas, the rate of HTLV-I carriers is high. A definite diagnosis of ATL is based on the presence of HTLV-I proviral DNA in the tumor cell DNA. ATL cells originate from the CD4 subset of peripheral T cells. ATL shows diverse clinical features but can be divided into four subtypes: the acute, chronic, smoldering, and lymphoma types. Chemotherapy is not effective; the acute and lymphoma types have a poor prognosis. Familiar occurrence of ATL is common. HTLV-I infection is caused by transmission of live infected lymphocytes from mother to child, or from man to woman, or by blood transfusion.
