Dual-elemental analysis of single particles using quadrupole-based inductively coupled plasma-mass spectrometry
Dual-elemental analysis of single particles using quadrupole-based inductively coupled plasma-mass spectrometry
复制标题
DOI：
10.1016/j.aca.2021.339389
复制
发表时间：
2021-12-27
影响因子：
6.2
通讯作者：
Leung, Kelvin Sze-Yin
中科院分区：
文献类型：
--
作者：
Chun, Ka-Him;Lum, Judy Tsz-Shan;Leung, Kelvin Sze-Yin
单颗粒电感耦合等离子体质谱 (SP-ICP-MS) 用于单颗粒和生物细胞的元素分析。飞行时间 (TOF) 质量分析仪广泛用于单个颗粒的多元素分析。由于质量分析仪的顺序性质，当监测一种以上元素时，基于四极杆的 ICP-MS 通常会产生较差的分析性能。在这项研究中，我们首次使用四极杆 ICP-MS 在氧气碰撞气体的帮助下对单个粒子进行精确的双质量测量。同时测量银纳米颗粒 (AgNP) 的 Ag-107 和 Ag-109 强度显示颗粒回收率为 100%，皮尔逊相关系数为 0.97，表明 ICP 中所有颗粒的采样正确。该技术提供了良好的测量精度（RSD
Single-particle inductively coupled plasma-mass spectrometry (SP-ICP-MS) is used for elemental analysis of single particles and biological cells. Time-of-flight (TOF) mass analyzers are widely used for multiple element analysis of individual particles. Owing to the sequential nature of the mass analyzer, quadrupole-based ICP-MS generally gives poor analytical performance when more than one element are being monitored. In this study, we present the first accurate and precise dual-mass measurement of individual particles using quadrupole-based ICP-MS, with the assistance of oxygen collision gas. Simultaneous measurement of the intensity of Ag-107 and Ag-109 of Ag nanoparticles (AgNP) showed particle recovery of 100% and Pearson correlation coefficient of 0.97, indicating proper sampling of all particles in the ICP. This technique gives good measurement precision (RSD