Cellular and Molecular Mechanisms of Chronic Obstructive Pulmonary Disease
Cellular and Molecular Mechanisms of Chronic Obstructive Pulmonary Disease
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DOI：
10.1016/j.ccm.2013.10.004
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发表时间：
2014-03-01
影响因子：
5.7
通讯作者：
Barnes, Peter J.
中科院分区：
文献类型：
--
作者：
Barnes, Peter J.
慢性阻塞性肺疾病与主要影响肺实质和外周气道的慢性炎症相关，并导致很大程度上不可逆和进行性气流受限。这种炎症的特征是从循环系统中募集的肺泡巨噬细胞、中性粒细胞和 T 淋巴细胞数量增加。氧化应激在驱动这种炎症中起着关键作用。肺部炎症可能会促进肺癌的发生和生长。外周炎症延伸到循环系统，导致具有相同炎症蛋白的全身炎症。全身炎症可能会使合并症恶化。因此，肺部炎症的治疗可能具有有益的效果。
Chronic obstructive pulmonary disease is associated with chronic inflammation affecting predominantly lung parenchyma and peripheral airways and results in largely irreversible and progressive airflow limitation. This inflammation is characterized by increased numbers of alveolar macrophages, neutrophils, and T lymphocytes, which are recruited from the circulation. Oxidative stress plays a key role in driving this inflammation. The pulmonary inflammation may enhance the development and growth of lung cancer. The peripheral inflammation extends into the circulation, resulting in systemic inflammation with the same inflammatory proteins. Systemic inflammation may worsen comorbidities. Treatment of pulmonary inflammation may therefore have beneficial effects.