Nanoscale Imaging Technology for THz Frequency Transmission Microscopy
Nanoscale Imaging Technology for THz Frequency Transmission Microscopy
复制标题
太赫兹频率透射显微镜纳米成像技术
DOI：
10.1142/s012915640800528x
复制
发表时间：
2008
影响因子：
--
通讯作者：
P. Burke
中科院分区：
文献类型：
--
作者：
P. Burke
提出了一种新的纳米尺度工程方法，具有潜力的第一次开发的显微镜系统能够收集太赫兹（THz）的频率光谱特征从微观生物（生物）结构。这种独特的太赫兹透射显微镜方法的动机是对生物材料和生物制剂的先前研究（例如，DNA、RNA和细菌孢子），其在THz频率范围内产生光谱特征（即，~ 300 GHz至1000 GHz），其似乎代表组成生物分子的内部结构和特性。建议的太赫兹透射显微镜是一种全新的技术方法，旨在避免传统实验中存在的局限性（即，必须在大量微观分子上求平均值），通过规定一种可行的技术，由此可以从单个生物分子和/或微观生物构建体收集THz频率特征。具体地说，可以设想开发一种“纳米级成像阵列”，其具有必要的特性（例如，亚波长分辨率），以成功地执行“太赫兹频率显微镜”。
A novel nanoscale-engineering methodology is presented that has potential for the first-time development of a microscope-system capable of collecting terahertz (THz) frequency spectroscopic signatures from microscopic biological (bio) structures. This unique THz transmission microscopy approach is motivated by prior studies on bio-materials and bio-agents (e.g., DNA, RNA and bacterial spores) that have produced spectral features within the THz frequency regime (i.e., ~ 300 GHz to 1000 GHz) that appear to be representative of the internal structure and characteristics of the constituent bio-molecules. The suggested THz transmission microscopy is a fundamentally new technological approach that seeks to avoid the limitations that exist in traditional experiments (i.e., that must average over large numbers of microscopic molecules) by prescribing a viable technique whereby the THz frequency signatures may be collected from individual bio-molecules and/or microscopic biological constructs. Specifically, it is possible to envision the development of a “nanoscale imaging array” that possesses the characteristics necessary (e.g., sub-wavelength resolution) for successfully performing “THz-frequency microscopy.”